Home
About the Program
Structure
Calendar 2017
Calendar 2016
Calendar 2015
Calendar 2014
Calendar 2013
Calendar 2012
Calendar 2011
Admissions
The Students
Research and Faculty
Coordinating Committee
Module Coordinators
Publications
PhD Degrees Completed
Events and Highlights
All Time GABBAs
Contacts
Reserved Area
Forgot your password?
News

In a recently published study in Nature Genetics, Joăo Curado (Gabba 12th edition) and colleagues proposed that genes with expression restricted to a specific developmental time point break the epigenetic rules.
Although levels of methylation at lysine 4 on histone H3 (H3K4me3), among others, are normally associated with activation and predictive of gene expression levels, this is not observed in genes regulated through development. Using published data from the modENCODE consortium, the team identified a surprising pattern of absence of these canonical marks of active chromatin in developmentally regulated genes, even when they were highly expressed. Strong histone marking was also associated with transcriptional stability including at the splicing level. These findings were validated experimentally and the next step will be to challenge mammalian developmental systems.
Link: http://www.nature.com/ng/journal/v47/n10/full/ng.3381.html
Published in 2015-10-08 16:41:25
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology