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Class of 2005
Name
Guedes de Melo, Sónia
Nationality
Portuguese
E-Mail
soniagmelo@gmail.com
1st Degree
Biochemistry
University (1st Degree)
FCUP
About the PhD
Field of Research
microRNAs biogenesis
Thesis Title
MicroRNA machinery in human cancers
Supervisor(s)
Doctor Manel Esteller, MD, PhD CNIO-Madrid / ICO-Barcelona
Co-Supervisor(s)
Fátima Carneiro, MD, PhD, HGSJ and IPATIMUP - Porto Carla Oliveira, PhD, IPATIMUP - Porto
University
University of Porto
Laboratory
Epigenetics lab
City
Madrid and Barcelona
Country
Spain
Date of Thesis Defence
2010-04-13
After the PhD (Current Situation)
Position
EMBO Post doctoral fellow
Project
MicroRNA biogenesis crosstalk on fibroblast reprogramming
Institution
Harvard Medical School
View Institution website
City
Boston
Country
USA

Relevant Publications
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nature Genetics
Sonia A Melo, Santiago Ropero, Catia Moutinho, Lauri A Aaltonen, Hiroyuki Yamamoto, George A Calin, Simona Rossi, Agustin F Fernandez, Fatima Carneiro, Carla Oliveira, Bibiana Ferreira, Chang-Gong Liu, Alberto Villanueva, Gabriel Capella, Simo Schwartz Jr, Ramin Shiekhattar & Manel Esteller
View Publication
Dysregulation of microRNAs in cancer: Playing with fire. FEBS Let
Sonia A. Melo, Manel Esteller
View Publication
A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells. Cancer Cell
Sonia A. Melo, Catia Moutinho, Santiago Ropero, George A. Calin, Simona Rossi, Riccardo Spizzo, Agustin F. Fernandez, Veronica Davalos, Alberto Villanueva, Guillermo Montoya, Hiroyuki Yamamoto, Simo Schwartz and Manel Esteller
View Publication
Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. PNAS
Sonia Melo, Alberto Villanueva, Catia Moutinho, Veronica Davalos, Riccardo Spizzo, Cristina Ivan, Simona Rossi, Fernando Setien, Oriol Casanovas, Laia Simo-Riudalbas, Javier Carmona, Jordi Carrere, August Vidale, Alvaro Aytes, Sara Puertas, Santiago Ropero, Raghu Kallurig, Carlo M. Croce, George A. Calin, and Manel Esteller
View Publication
A precursor microRNA in a cancer cell nucleus: Get me out of here! Cell Cycle
Melo SA, Esteller M.
View Publication

Publications
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Research
Fernandez AF, Rosales C, Lopez-Nieva P, Graña O, Ballestar E, Ropero S, Espada J, Melo SA, Lujambio A, Fraga MF, Pino I, Javierre B, Carmona FJ, Acquadro F, Steenbergen RD, Snijders PJ, Meijer CJ, Pineau P, Dejean A, Lloveras B, Capella G, Quer J, Buti M, Esteban JI, Allende H, Rodriguez-Frias F, Castellsague X, Minarovits J, Ponce J, Capello D, Gaidano G, Cigudosa JC, Gomez-Lopez G, Pisano DG, Valencia A, Piris MA, Bosch FX, Cahir-McFarland E, Kieff E, Esteller M.
View Publication
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene
Lujambio A, Portela A, Liz J, Melo SA, Rossi S, Spizzo R, Croce CM, Calin GA, Esteller M.
View Publication
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology