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Class of 1997
Name
Jerónimo, Carmen
Nationality
Portuguese
E-Mail
carmenjeronimo@ipoporto.min-saude.pt
1st Degree
Biology
University (1st Degree)
University of Porto
Master Degree
Oncology
University (Master Degree)
Institute of Biomedical Sciences Abel Salazar - University of Porto
About the PhD
Field of Research
Cancer Genetics and Epigenetics
Thesis Title
Molecular Detection of Prostate Cancer
Abstract
Since prostate cancer is the most common malignancy in men in industrialized countries, and its incidence, morbidity and mortality have been increasing in recent years, this Thesis was aimed at identifying genetic abnormalities...
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Supervisor(s)
David Sidransky, MD;Head & Neck Cancer Research Division, Johns Hopkins University, Baltimore, MD, USA &Carlos Lopes, MD, PhD; Department of Pathology; Portuguese Oncology Institute - Porto; Potugal
University
Institute of Biomedical Sciences Abel Salazar of University of Porto
Laboratory
Head & Neck Cancer Research Division-Johns Hopkins Medical School & Dpt of Pathology of Portuguese Oncology Institute-Porto
Date of Thesis Defence
2001-10-24
After the PhD (Current Situation)
Position
Group Leader of Cancer Epigenetics Group-Research Center of (CI-IPOP)&Guest Associate Professor- Departament of Pathology and Molecular Imunology
Institution
Portuguese Oncology Institute-Porto & ICBAS-University of Porto
View Institution website
City
Porto
Country
Portugal

Relevant Publications
Costa V L, Henrique R, Ribeiro FR, Carvalho JR, Oliveira J, Lobo F, Teixeira MR, Jerónimo C. Epigenetic regulation of Wnt-signaling pathway in urological tumors. Epigenetics 16;5(4):343-51, 2010.
Carvalho JR, Filipe L, Costa VL, Ribeiro FR, Martins AT, Teixeira MR, Jerónimo C, Henrique R. Detailed analysis of expression and promoter methylation status of apoptosis-related genes in prostate cancer. Apoptosis 15(8):956-65, 2010.
Jerónimo C, Esteller M. DNA Methylation Markers for Prostate Cancer with a Stem Cell Twist. Cancer Prev Res (Phila Pa) 3(9):1053-5, 2010.
Costa VL, Henrique R, Danielsen SA, Duarte-Pereira S, Eknaes M, Skotheim RI, Rodrigues A, Magalhăes JS, Oliveira J, Lothe RA, Teixeira MR, Jeronimo C*, Lind GE*.Three epigenetic biomarkers, GDF15, TMEFF2 and VIM, accurately predict bladder cancer from DNA-based analyses of urine samples. Clin Cancer Res 16(23):5842-51, 2010. (*should be regarded as joint senior authors).
Jerónimo C, Nomoto S, Caballero O, Usadel H, Henrique R, Varzim G, Oliveira J, Lopes C, Fliss M, Sidransky D. Mitochondrial mutations in early stage prostate cancer and bodily fluids. Oncogene 20: 5195-5198, 2001.
Jerónimo C, Usadel H, Henrique R, Oliveira J, Lopes C, Nelson WG, Sidransky D. Quantitation of GSTP1 methylation in non-neoplastic prostatic tissue and organ confined prostate adenocarcinoma. J Natl Cancer Inst 93(22): 1747-52, 2001.
Jerónimo C, Varzim G, Henrique R, Oliveira J, Bento MJ, Silva C, Lopes C, Sidransky D. I105V polymorphism and promoter methylation of GSTP1 gene in prostate adenocarcinoma. Cancer Epidemiol Biomark Prev 11(5): 445-50, 2002.
Jerónimo C, Usadel H, Henrique R, Silva C, Oliveira J, Lopes C, Sidransky D. Quantitative GSTP1 hypermethylation in bodily fluids of prostate cancer patients. Urology 60: 1131-1135, 2002
Jerónimo C, Costa I, Martins MC, Monteiro P, Lisboa S, Sousa CP, Henrique R, Teixeira MR, Lopes C. Detection of gene promoter hypermethylation in fine needle washings from breast lesions. Clin Cancer Res 9: 3413-3417, 2003
Jerónimo C*, Henrique R*, Hoque MO, Ribeiro FR, Oliveira J, Fonseca D, Teixeira MR, Lopes C, Sidransky D. Quantitative RARβ2 hypermethylation: a promising prostate cancer marker. Clin Cancer Research 10: 4010-4014, 2004
Henrique R, Jerónimo C. Molecular detection of prostate cancer: a role for GSTP1 hypermethylation. Eur Urol 46(5): 660-669, 2004
Henrique R*, Jerónimo C*, Hoque MO, Carvalho AL, Costa VL, Oliveira J, Teixeira MR, Lopes C, Sidransky D. MT1G hypermethylation is associated with higher tumor stage in prostate cancer. Cancer Epidemiol Biomarkers Prev 14(5): 1274-1278, 2005.
Henrique R*, Jerónimo C*, Teixeira MR, Hoque MO, Carvalho AL, Pais I, Ribeiro FR, Oliveira J, Lopes C, Sidransky D. Epigenetic heterogeneity of high-grade prostatic intraepithelial neoplasia: clues for clonal progression in prostate carcinogenesis. Mol Cancer Res 4(1):1-8, 2006.
Hoque MO, Feng Q, Toure P, Dem A, Critchlow CW, Hawes SE, Wood T, Jerónimo C, Rosenbaum E, Stern J, Yu M, Trink B, Kiviat NB, Sidransky D. Detection of Aberrant Methylation of Four Genes in Plasma DNA for the Detection of Breast Cancer. J Clin Oncol 24: 24(26): 4262-9, 2006.
Cerveira N, Ribeiro FR, Peixoto A, Costa VL, Henrique R, Jerónimo C, Teixeira MR. TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions. Neoplasia 8:826-832, 2006.
Henrique R, Costa VL, Cerveira N, Carvalho AL, Hoque MO, Ribeiro FR, Oliveira J, Teixeira MR, Sidransky D, Jerónimo C. Hypermethylation of Cyclin D2 is associated with loss of expression and tumor progression in prostate cancer. J Mol Med 84:911-918, 2006.
Costa VL, Henrique R, Ribeiro FR, Pinto M, Oliveira J, Lobo F, Teixeira MR, Jerónimo C. Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors. BMC Cancer 7:133, 2007.
Henrique R, Ribeiro FR, Fonseca D, Hoque MO, Carvalho AL , Costa VL, Pinto M, Oliveira J, Teixeira MR, Sidransky D, Jerónimo C. High Promoter methylation levels of APC predict poor prognosis in sextant biopsies from prostate cancer patients. Clin Cancer Res 13:6122 -6129, 2007.
Carvalho AL, Jeronimo C, Kim MM, Henrique R, Zhang Z, Hoque MO, Chang S, Brait M, Nayak CS, Jiang WW, Claybourne Q, Tokumaru Y, Lee J, Goldenberg D, Garrett-Mayer E, Goodman S, Moon CS, Koch W, Westra WH, Sidransky D, Califano JA. Evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res 14(1):97-107, 2008.
Liu JW, Nagpal JK, Jeronimo C, Lee JE, Henrique R, Kim MS, Ostrow KL, Yamashita K, van Criekinge V, Wu G, Moon CS, Trink B, Sidransky D. Hypermethylation of MCAM gene is associated with advanced tumor stage in prostate cancer. Prostate 68(4):418-26, 2008.
Hoque MO, Begum S, Brait M, Jeronimo C, Henrique R, Wisman GB, van der Zee AG Sidransky D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res 68(8):2661-70, 2008.
Jerónimo C, Monteiro P, Henrique R, Dinis-Ribeiro M, Costa I, Costa VL, Filipe L, Carvalho AL, Hoque MO, Pais I, Leal C, Teixeira MR, Sidransky D. Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fine-needle aspirate washings of breast lesions. Breast Cancer Res Treat 109(1):27-34, 2008.

Publications
Liu J-W, Nagpal J, Sun W, Lee J, Kim M, Ostrow K, Zhou S, Jeronimo C, Henrique R, van Criekinge W, Moon C, Califano J, Trink B, Sidransky D. SSBP2 is frequently hypermethylated and suppresses cell growth in human prostate cancer. Clin Cancer Res 14(12):3754-60, 2008.
Soares MJ, Pinto M, Henrique R, Vieira J, Cerveira N, Peixoto A, Martins A, Oliveira J, Jerónimo C, Teixeira MR. CSF1R copy number changes, point mutations and RNA and protein overexpression in renal cell carcinomas. Mod Pathol 22:744-752, 2009.
Pinto M, Vieira J, Ribeiro FR, Soares MJ, Henrique R, Oliveira J, Jerónimo C,Teixeira MR. Overexpression of the mitotic checkpoint genes BUB1 and BUBR1 is associated with genomic complexity in clear cell kidney carcinomas. Cell Oncol 30(5):389-95, 2008.
Soares MJ, Pinto M, Henrique R, Vieira J, Cerveira N, Peixoto A, Martins A, Oliveira J, Jerónimo C, Teixeira MR. CSF1R copy number changes, point mutations and RNA and protein overexpression in renal cell carcinomas. Mod Pathol 22:744-752, 2009.
Carvalho M, Ferreira PJ, Mendes VS, Silva R, Pereira JA, Jerónimo C, Silva MB. Human cancer cell antiproliferative and antioxidant activities of Juglans regia L. Food Chem Toxicol 48(1):441-750, 2010.

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