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Class of 2006
Name
Costa, Guilherme
E-Mail
guilherme.mc.costa@gmail.com
1st Degree
Biology
University (1st Degree)
Universidade de Lisboa
About the PhD
Field of Research
Stem Cell Haematopoiesis
Thesis Title
Exploring the role of SOX7 in the specification of the haemogenic endothelium
Abstract
During vertebrate ontogeny the haemangioblast generates the first blood cells through an endothelial stage with haemogenic properties. Although several transcription factors have been implicated in the development of the...
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Supervisor(s)
Dr. Valerie Kouskoff
University
University of Manchester
Laboratory
Paterson Institute for Cancer Research
City
Manchester
Country
UK
Date of Thesis Defence
2011-07-13
After the PhD (Current Situation)
Position
Postdoctoral researcher
Project
Molecular control of vascular development and angiogenesis
Institution
University of Manchester
City
Manchester
Country
UK

Relevant Publications
Guilherme Costa, Andrzej Mazan, Arnaud Gandillet, Stella Pearson, Georges Lacaud, and Valerie Kouskoff
SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development
Development 2012;139 1587-1598
View Publication

Publications
Costa G, Kouskoff V, Lacaud G.
Origin of blood cells and HSC production in the embryo.
Trends Immunol. May, 2012 Volume 33, Issue 5
View Publication
Christophe Lancrin, Milena Mazan, Monika Stefanska, Rahima Patel, Monika Lichtinger, Guilherme Costa, Özge Vargel, Nicola K. Wilson, Tarik Möröy, Constanze Bonifer, Berthold Göttgens, Valerie Kouskoff and Georges Lacaud
GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment
Blood 2012;120 314-322
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Perez-Campo FM, Costa G, Lie-a-Ling M, Kouskoff V, Lacaud G. The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis. Immunology 2013; 139(2):161-5.
View Publication
Perez-Campo FM, Costa G, Lie-A-Ling M, Stifani S, Kouskoff V, Lacaud G. MOZ-mediated repression of p16INK4a is critical for the self-renewal of neural and hematopoietic stem cells. Stem Cells 2013
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Stefanska M, Costa G, Lie-A-Ling M, Kouskoff V, Lacaud G. Smooth muscle cells largely develop independently of functional hemogenic endothelium. Stem Cell Res. 2014 Jan;12(1):222-32
View Publication
Last Update
2014-01-07 10:19:36
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology