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Class of 2006
Name
Barreira da Silva, Rosa
Nationality
Portuguese
E-Mail
rosabarreira@gmail.com
1st Degree
Biochemistry
University (1st Degree)
University of Porto
About the PhD
Field of Research
Immunology
Thesis Title
Study of immunological synapses between human dendritic cells and natural killer cells
Abstract
The immune system is a complex organ that includes different types of cells, tissues and molecules. These components are coordinated very elegantly and efficiently, in order to maintain integrity and health of the human body,...
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Supervisor(s)
Christian Münz
Co-Supervisor(s)
Paula Ferreira
University
Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto
Laboratory
Laboratory of Viral Immunobiology - The Rockefeller University, NY, USA; Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
City
New York / Zürich
Country
USA / Switzerland
Date of Thesis Defence
2011-12-22
After the PhD (Current Situation)
Position
Posdoctoral researcher
Project
Lymphocyte trafficking and tumor Immunity
Institution
Instiut Pasteur
View Institution website
City
Paris
Country
France

Relevant Publications
Barreira da Silva, R., Graf, C. and Münz, C. (2011) Cytoskeletal stabilization of inhibitory interactions in immunological synapses of mature human dendritic with natural killer cells, Blood, 118(25):6487-98 Epub 2011 Sep 13.
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Barreira da Silva, R. and Münz, C. (2011) Natural killer cell activation by dendritic cells: balancing inhibitory and activating signals, Cell Mol Life Sci. 68(21):3505-18
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Romano, E., Cotari, JW.,* Barreira da Silva, R.,* Betts, B., Chung, DJ., Mitsu, FJ., Avogadri, F., Angelo, ES., Mehrara, B., Heller, G., Münz, C., Altan-Bonnet, G. and Young, JW. (2012) “Human Langerhans cells use an IL15Rα/IL15/pSTAT5-dependent mechanism to break T cell tolerance against the self-differentiation tumor antigen, WT1” Blood Epub ahead of print. * Equal contributors
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Barreira da Silva R, Laird ME, Yatim N, Fiette L, Ingersoll MA, Albert ML. (2015) Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy. Nat Immunol. [Epub ahead of print]
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Publications
Lünemann A, Lünemann JD, Roberts S, Messmer B, Barreira da Silva R, Raine CS and Münz C. (2008) Human NK cells kill resting but not activated microglia via NKG2D- and NKp46-mediated recognition, J Immunol. 181(9):6170-7
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Lünemann A, Tackenberg B, DeAngelis T, da Silva RB, Messmer B, Vanoaica LD, Miller A, Apatoff B, Lublin FD, Lünemann JD and Münz C. (2011) Impaired IFN-γ production and proliferation of NK cells in multiple sclerosis. Int Immunol. 23(2):139-48.
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Gannage M, da Silva RB and Münz C. (2013) Antigen processing for MHC presentation via macroautophagy, Methods Mol Biol. 960:473-88
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Carvalho S, Barreira da Silva R, Shawki A, Castro H, Lamy M, Eide D, Costa V, Mackenzie B, Tomás AM. (2015) LiZIP3 is a cellular zinc transporter that mediates the tightly regulated import of zinc in Leishmania infantum parasites. Mol Microbiol. 96(3):581-95
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Last Update
2015-06-26 20:12:42
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology