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Class of 2007
Name
Sousa, André
Nationality
Portuguese
E-Mail
andre.sousa@yale.edu
1st Degree
Biology
University (1st Degree)
University of Porto
About the PhD
Field of Research
Neuroscience
Thesis Title
Human brain development and evolution: Insights from gene expression
Abstract
Discovering the basis for the unique properties of the human brain is a major goal of modern science. Yet, many fundamental gaps remain in our knowledge of the human brain development and evolution.
In this study we analyzed...
more
Supervisor(s)
Nenad Sestan
Co-Supervisor(s)
José Castro Lopes
University
Abel Salazar Biomedical Sciences Institute, University of Porto
Laboratory
Sestan Lab, Yale School of Medicine Department of Neurobiology
City
New Haven, CT
Country
USA
Date of Thesis Defence
2013-07-26

Relevant Publications
Pletikos M*, Sousa AMM*, Sedmak G*, Meyer KA, Zhu Y, Cheng F, Li M, Kawasawa YI, Sestan N (2014) Temporal specification and bilaterality of human neocortical topographic gene expression. Neuron. 81(2):321-32.
* Equal contribution
View Publication
Onorati M*, Li Z*, Liu F*, Sousa AMM*, Nakagawa N, Li M, Dell’Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao X-B, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N (2016) Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports 16, 1–17
* Equal contribution
View Publication
Sousa AMM*, Meyer KA*, Santepere G, Gulden FO, Sestan N (2017) Evolution of the Human Nervous System Function, Structure, and Development. Cell 170, 226 - 247
* Equal contribution
View Publication

Publications
Kang HJ*, Kawasawa YI*, Cheng F*, Zhu Y*, Xu X*, Li M*, Sousa AMM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE, Sestan N (2011) Spatio-temporal transcriptome of the human brain. Nature. 2011 Oct 26;478 (7370) :483-9. Epub 2011 Oct 26. PMID: 22031440
* Equal contribution
View Publication
Kwan KY, Lam MMS, Johnson MB, Dube U, Shim S, Rasin MR, Sousa AMM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P, Heffer M, Kostovic I, Judas M, Sestan N (2012) Species-dependent post-transcriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell. 2012 May 11;149 (4) :899-911. PMID: 22579290
View Publication
Miller DJ, Duka T, Stimpson CD, Schapiro SJ, Baze WB, McArthur MJ, Fobbs AJ, Sousa AMM, Sestan N, Wildman DE, Lipovich L, Kuzawa CW, Hof PR, Sherwood CC (2012) Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci U S A. 2012 Oct 9;109 (41) :16480-5. Epub 2012 Sep 24. PMID: 23012402
View Publication
Zhu Y, Li M, Sousa AMM, Sestan N (2014) XSAnno: a framework for building ortholog models in cross-species transcriptome comparisons. BMC Genomics. 2014, 15:343
View Publication
Sousa AMM*, Meyer KA*, Sestan N (2014) Molecular and Cellular Mechanisms of Human Brain Development and Evolution. In The Cognitive Neurosciences , 5th edition. Gazzaniga MS, Mangun GR, Eds., The MIT Press, pp. 67-74
* Equal contribution

[more publications]
Last Update
2014-09-22 19:46:05

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