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Class of 2007
Sousa, André
1st Degree
University (1st Degree)
University of Porto
About the PhD
Field of Research
Thesis Title
Human brain development and evolution: Insights from gene expression
Discovering the basis for the unique properties of the human brain is a major goal of modern science. Yet, many fundamental gaps remain in our knowledge of the human brain development and evolution.
In this study we analyzed...
Nenad Sestan
José Castro Lopes
Abel Salazar Biomedical Sciences Institute, University of Porto
Sestan Lab, Yale School of Medicine Department of Neurobiology
New Haven, CT
Date of Thesis Defence

Relevant Publications
Pletikos M*, Sousa AMM*, Sedmak G*, Meyer KA, Zhu Y, Cheng F, Li M, Kawasawa YI, Sestan N (2014) Temporal specification and bilaterality of human neocortical topographic gene expression. Neuron. 81(2):321-32.
* Equal contribution
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Onorati M*, Li Z*, Liu F*, Sousa AMM*, Nakagawa N, Li M, Dell’Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao X-B, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N (2016) Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports 16, 1–17
* Equal contribution
View Publication
Sousa AMM*, Meyer KA*, Santepere G, Gulden FO, Sestan N (2017) Evolution of the Human Nervous System Function, Structure, and Development. Cell 170, 226 - 247
* Equal contribution
View Publication
Sousa AMM*, Zhu Y*, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamo ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edles MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N (2017) Molecular and cellular reorganization of neural circuits in the human lineage. Science 358, 1027-1032
* Equal contribution
View Publication
Zhu Y*, Sousa AMM*, Gao T*, Skarica M*, Li M*, Santpere G, Esteller-Cucala P, Juan D, Ferrandez-Peral L, Golden FO, Yang M, Miller DJ, Marques-Bonet T, Kawasawa YI, Zhao H, Sestan N (2018) Spatiotemporal transcriptomic divergence across human and macaque brain development. Science 362, eaat8077. * Equal contribution
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Kang HJ*, Kawasawa YI*, Cheng F*, Zhu Y*, Xu X*, Li M*, Sousa AMM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE, Sestan N (2011) Spatio-temporal transcriptome of the human brain. Nature. 2011 Oct 26;478 (7370) :483-9. Epub 2011 Oct 26. PMID: 22031440
* Equal contribution
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Kwan KY, Lam MMS, Johnson MB, Dube U, Shim S, Rasin MR, Sousa AMM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P, Heffer M, Kostovic I, Judas M, Sestan N (2012) Species-dependent post-transcriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell. 2012 May 11;149 (4) :899-911. PMID: 22579290
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Miller DJ, Duka T, Stimpson CD, Schapiro SJ, Baze WB, McArthur MJ, Fobbs AJ, Sousa AMM, Sestan N, Wildman DE, Lipovich L, Kuzawa CW, Hof PR, Sherwood CC (2012) Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci U S A. 2012 Oct 9;109 (41) :16480-5. Epub 2012 Sep 24. PMID: 23012402
View Publication
Zhu Y, Li M, Sousa AMM, Sestan N (2014) XSAnno: a framework for building ortholog models in cross-species transcriptome comparisons. BMC Genomics. 2014, 15:343
View Publication
Sousa AMM*, Meyer KA*, Sestan N (2014) Molecular and Cellular Mechanisms of Human Brain Development and Evolution. In The Cognitive Neurosciences , 5th edition. Gazzaniga MS, Mangun GR, Eds., The MIT Press, pp. 67-74
* Equal contribution

[more publications]
Last Update
2014-09-22 19:46:05

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