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Class of 2007
Sousa, André
1st Degree
University (1st Degree)
University of Porto
About the PhD
Field of Research
Thesis Title
Human brain development and evolution: Insights from gene expression
Discovering the basis for the unique properties of the human brain is a major goal of modern science. Yet, many fundamental gaps remain in our knowledge of the human brain development and evolution.
In this study we analyzed...
Nenad Sestan
José Castro Lopes
Abel Salazar Biomedical Sciences Institute, University of Porto
Sestan Lab, Yale School of Medicine Department of Neurobiology
New Haven, CT
Date of Thesis Defence

Relevant Publications
Mihovil Pletikos*, André M.M. Sousa*, Goran Sedmak*, Kyle A. Meyer, Ying Zhu, Feng Cheng, Mingfeng Li, Yuka Imamura Kawasawa, Nenad Šestan (2014) Temporal specification and bilaterality of human neocortical topographic gene expression. Neuron. 81(2):321-32.
* Equal contribution
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Marco Onorati*, Zhen Li*, Fuchen Liu*, André M.M. Sousa*, Naoki Nakagawa, Mingfeng Li, Maria Teresa Dell’Anno, Forrest O. Gulden, Sirisha Pochareddy, Andrew T.N. Tebbenkamp, Wenqi Han, Mihovil Pletikos, Tianliuyun Gao, Ying Zhu, Candace Bichsel, Luis Varela, Klara Szigeti-Buck, Steven Lisgo, Yalan Zhang, Anze Testen, Xiao-Bing Gao, Jernej Mlakar, Mara Popovic, Marie Flamand, Stephen M. Strittmatter, Leonard K. Kaczmarek, E.S. Anton, Tamas L. Horvath, Brett D. Lindenbach, Nenad Sestan (2016) Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia. Cell Reports 16, 1–17
* Equal contribution
View Publication

Kang HJ*, Kawasawa YI*, Cheng F*, Zhu Y*, Xu X*, Li M*, Sousa AMM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE, Sestan N (2011) Spatio-temporal transcriptome of the human brain. Nature. 2011 Oct 26;478 (7370) :483-9. Epub 2011 Oct 26. PMID: 22031440
* Equal contribution
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Kwan KY, Lam MMS, Johnson MB, Dube U, Shim S, Rasin MR, Sousa AMM, Fertuzinhos S, Chen JG, Arellano JI, Chan DW, Pletikos M, Vasung L, Rowitch DH, Huang EJ, Schwartz ML, Willemsen R, Oostra BA, Rakic P, Heffer M, Kostovic I, Judas M, Sestan N (2012) Species-dependent post-transcriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell. 2012 May 11;149 (4) :899-911. PMID: 22579290
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Miller DJ, Duka T, Stimpson CD, Schapiro SJ, Baze WB, McArthur MJ, Fobbs AJ, Sousa AMM, Sestan N, Wildman DE, Lipovich L, Kuzawa CW, Hof PR, Sherwood CC (2012) Prolonged myelination in human neocortical evolution. Proc Natl Acad Sci U S A. 2012 Oct 9;109 (41) :16480-5. Epub 2012 Sep 24. PMID: 23012402
View Publication
Ying Zhu, Mingfeng Li, André MM Sousa, Nenad Sestan (2014) XSAnno: a framework for building ortholog models in cross-species transcriptome comparisons. BMC Genomics. 2014, 15:343
View Publication
Sousa AMM*, Meyer KA*, Sestan N (2014) Molecular and Cellular Mechanisms of Human Brain Development and Evolution. In The Cognitive Neurosciences , 5th edition. Gazzaniga MS, Mangun GR, Eds., The MIT Press, pp. 67-74
* Equal contribution

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Last Update
2014-09-22 19:46:05
Program financially supported by
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