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| Name |
| Curado, João |
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| Nationality |
| Portuguese |
| E-Mail |
| Joao.curado@crg.eu |
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| Master Degree |
| Bioinformatics |
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| About the PhD |
| Field of Research |
| Bioinformatics & Genomics |
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| Thesis Title |
| Chromatin: new insights into splicing |
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| Abstract |
| Chromatin states have been characterized with great detail. Here we explored transcription of developmental regulated genes in the context of chromatin. We found that these genes are expressed in the absence of canonically... |
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Chromatin states have been characterized with great detail. Here we explored transcription of developmental regulated genes in the context of chromatin. We found that these genes are expressed in the absence of canonically active histone modifications and possibly under stronger regulation of transcription factors.
Using a broad panel of human cell lines we also identified a subset of exons whose inclusion level is strongly correlated with the presence of some chromatin features. These exons are in close proximity of active promoters. |
| close |
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| Supervisor(s) |
| Roderic Guigó |
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| Co-Supervisor(s) |
| Alexandra Moreira |
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| University |
| Universidade do Porto | Centre de Regulaciò Genómica |
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| Laboratory |
| Computational biology of RNA processing |
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| City |
| Barcelona |
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| Country |
| Spain |
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| Date of Thesis Defence |
| 2015-11-20 |
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| After the PhD (Current Situation) |
| Position |
| CEO and Bioinformatics researcher |
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| Project |
| Plasma RNA sequencing for diagnostics |
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| Institution |
| Flomics & CRG |
| View Institution website |
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| City |
| Barcelona |
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| Country |
| Spain |
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| Relevant Publications |
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Pérez-Lluch S*, Blanco E*, Tilgner H*, Curado J*, Ruiz-Romero M, Corominas M, Guigó, R Absence of canonical marks of active chromatin in developmentally regulated genes
Nature Genetics 47, 1158–1167 (2015) doi:10.1038/ng.3381 |
| View Publication |
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Curado J, et al. Promoter-like epigenetic signatures in exons displaying cell type-specific splicing
Genome Biology 2015, 16:236 doi:10.1186/s13059-015-0797-8 |
| View Publication |
| Publications |
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Tilgner H, Knowles DG, Johnson R, Davis CA, Chakrabortty S, Djebali S, Curado J, Snyder M, Gingeras TR, Guigó R.
Deep sequencing of subcellular RNA fractions shows splicing to be predominantly co-transcriptional in the human genome but inefficient for lncRNAs
Genome Res. 2012 Sep;22(9):1616-25. |
| View Publication |
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Sarah Djebali, et al.
Landscape of transcription in human cells
Nature. 2012 Sep 6;489(7414):101-8. doi: 10.1038/nature11233. |
| View Publication |
| Last Update |
| 2015-12-07 17:07:29 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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