|
|
|
| Name |
| Oliveira, Cláudia |
|
| Nationality |
| Portuguese |
| E-Mail |
| claudia.ba@gmail.com |
|
| 1st Degree |
| Applied Biology |
|
| University (1st Degree) |
| University of Minho |
|
| About the PhD |
| Field of Research |
| Immunology |
|
| Thesis Title |
| Alternative antigen processing and presentation pathways by tumors |
|
| Abstract |
| The study of the natural immune response against cells with a defective function of the peptide transporter TAP led to the discovery of peptides presented by such TAP-deficient cells. Some of these peptides were recognized... |
| more |
| The study of the natural immune response against cells with a defective function of the peptide transporter TAP led to the discovery of peptides presented by such TAP-deficient cells. Some of these peptides were recognized by cytotoxic T-lymphocytes (CTL) and constituted specific antigens to these CTL. These CTL were capable of killing TAP-deficient tumor cells but not normal cells. The peptides presented specifically by TAP-deficient cells were called “T-cell epitopes associated with impaired peptide processing” (TEIPP). The studies of TEIPP antigens thus far have revealed that these antigens are promising candidates for the combat of cells with molecular defects in the pathways of antigen processing and presentation, such as tumors and virus-infected cells that normally escape immune-surveillance. However, several aspects about TEIPPs needed clarification: what are the processing pathways that lead to generation and presentation of TEIPP antigens; what is the mechanism behind the immunogenicity of TEIPPs; what are the characteristics of TEIPP peptides presented by non-classical Major Histocompatibility Complex class I (MHC-I) molecules. These topics are discussed in my PhD thesis. |
| close |
|
|
| Supervisor(s) |
| Prof. Dr. Sjoerd H. van der Burg |
|
| Co-Supervisor(s) |
| Dr. T. van Hall |
|
| University |
| Leiden University Medical Center |
|
| Laboratory |
| Clinical Oncology |
|
| City |
| Leiden |
|
| Country |
| The Netherlands |
|
| Date of Thesis Defence |
| 2013-12-10 |
|
|
| Relevant Publications |
|
| Oliveira CC, van Veelen PA, Querido B, de Ru A, Sluijter M, Laban S, van der Burg SH, Offringa R and van Hall T. The nonpolymorphic MHC Qa-1b mediates CD8+ T cell surveillance of antigen-processing defects. The Journal of Experimental Medicine 2010, 207(1): 207-221. |
| View Publication |
| Publications |
|
| van Hall T, Oliveira CC, Joosten SA, Ottenhoff TH. The other Janus face of Qa-1 and HLA-E: diverse peptide repertoires in times of stress. Microbes and Infection 2010, 12(12-13): 910-918. |
| View Publication |
|
| Oliveira CC, Querido B, Sluijter M, Derbinski J, van der Burg SH, van Hall T. Peptide transporter TAP mediates between competing antigen sources generating distinct surface MHC class I peptide repertoires. European Journal of Immunology 2011, 41(11): 3114-3124. |
| View Publication |
|
| Seidel UJ, Oliveira CC, Lampen MH, Hall T. A novel category of antigens enabling CTL immunity to tumor escape variants: Cinderella antigens. Cancer Immunology, Immunotherapy 2012, 61(1): 119-125. |
| View Publication |
|
| Oliveira CC, van Hall T. Importance of TAP-independent processing pathways. Molecular Immunology 2013, 55(2): 113-116. |
| View Publication |
|
| Oliveira CC, Querido B, Sluijter M, de Groot AF, van der Zee R, Rabelink MJWE, Hoeben RC, Ossendorp F, van der Burg SH, van Hall T. New role of signal peptide peptidase to liberate C-terminal peptides for MHC class-I presentation. The Journal of Immunology, 2013, 191(8):4020-8 |
| View Publication |
[more publications]
| More Publications |
|
| Oliveira CC, Sluijter M, Querido B, Ossendorp F, van der Burg SH, van Hall T. Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire. Molecular Immunology 2014, 62(1):129-136 |
| View Publication |
| Last Update |
| 2014-07-21 21:55:00 |
| The responsibility for this page contents is entirely of the student/alumnus. |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
Program financially supported by
the National Foundation for
Science and Technology
|
|
 |
|
