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| Name |
| Rosa, André |
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| Nationality |
| Portuguese |
| E-Mail |
| andreangeloo@gmail.com |
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| 1st Degree |
| Applied Chemistry |
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| University (1st Degree) |
| Universidade Nova de Lisboa |
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| Master Degree |
| Applied Chemistry |
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| University (Master Degree) |
| Universidade Nova de Lisboa |
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| About the PhD |
| Field of Research |
| Developmental Biology |
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| Thesis Title |
| The regulation and function of cortical actin remodelling upon entry into mitosis |
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| Abstract |
Entry into mitosis is accompanied by dramatic changes in the
morphology and polarity of cells, both of which entail remodelling of the cortical actomyosin cytoskeleton. Here I identified Diaphanous as the main actin nucleator... |
| more |
Entry into mitosis is accompanied by dramatic changes in the
morphology and polarity of cells, both of which entail remodelling of the cortical actomyosin cytoskeleton. Here I identified Diaphanous as the main actin nucleator required for the formation of the mitotic actin cortex in the context of a developing epithelium. I also identify the pathway involved, which we show is dependent on Pebble/RhoA and on the apical polarity regulators aPKC/Cdc42/Par6. Strikingly, following the activation of Pbl upon entry into mitosis, Cdc42 RhoGTPase and the polarity proteins aPKC and Par6 extend their domain more basally driving the cortical accumulation of Dia, while Rho directs the accumulation of cortical p-Myosin II. Taken together, these data reveal a new molecular mechanism for the concerted activation and localization of Dia via RhoGTPases and the intimate link between cortical repolarisation and the regulation of actin filament organisation. |
| close |
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| Supervisor(s) |
| Buzz Baum |
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| University |
| University College London |
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| Laboratory |
| Cell Morphogenesis |
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| City |
| London |
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| Country |
| United Kingdom |
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| Date of Thesis Defence |
| 2013-11-29 |
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| After the PhD (Current Situation) |
| Position |
| Pos-Doc |
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| Institution |
| London Research Institute |
| View Institution website |
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| City |
| London |
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| Country |
| UK |
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| Relevant Publications |
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| Identification of mating type genes in the bipolar basidiomycetous yeast Rhodosporidium toruloides: first insight into the MAT locus structure of the Sporidiobolales |
| View Publication |
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| Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development |
| View Publication |
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| Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry |
| View Publication |
| Last Update |
| 2014-07-16 14:35:25 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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