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| Name |
| Ataíde, Ricardo |
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| Nationality |
| Portuguese |
| E-Mail |
| ric.ataide@gmail.com |
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| 1st Degree |
| Biotech Engineering |
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| University (1st Degree) |
| Universidade Lusófona, Portugal |
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| About the PhD |
| Field of Research |
| Immunology |
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| Thesis Title |
| Malaria in Pregnancy - HIV and Phagocytosis |
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| Abstract |
| For millions of pregnant women all over the world the Plasmodium falciparum parasite represents one of the biggest threats they face. Infections with this parasite can result in a condition called Malaria in Pregnancy. The... |
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For millions of pregnant women all over the world the Plasmodium falciparum parasite represents one of the biggest threats they face. Infections with this parasite can result in a condition called Malaria in Pregnancy. The Malaria in Pregnancy effects can be felt by the pregnant women or by the foetus. Women in their first pregnancies are at highest risk of infection and as a result more prone to experience advserve effects, which can be made worse if they also exhibit an HIV infection. In women with already one or more pregnancies, the existence of antibodies against a type of Plasmodium falciparum that mainly infects pregnant women prtects them from Malaria in Pregnancy.
In this thesis I have developed a new assay that allows the quantification and assessement of phagocytic function of antibodies agaisnt those parasites. I have measured these antibodies in primigravidae and secundigravidae in the context of HIV infection. That allowed me to find that in primigravidae HIV primarily impacts on the acquisition of the antibodies and that in secundigravidae these antibodies are associated with a higher birth weight of the babies. I also demonstrated, for the first time, a possible involvement of IgE in the induction of phagocytosis of Plasmodium falciparum parasites |
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| Supervisor(s) |
| Prof Stephen Rogerson |
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| Co-Supervisor(s) |
| Dr António Amorim Dr Maria Manuel Mota |
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| University |
| Universidade do Porto (Portugal)/University of Melbourne (Australia) |
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| Laboratory |
| Malaria Lab, Dpt of Medicine, Melbourne University |
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| City |
| Melbourne |
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| Country |
| Australia |
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| Date of Thesis Defence |
| 2011-04-04 |
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| After the PhD (Current Situation) |
| Position |
| Research Officer |
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| Project |
| Immune correlates of resistance to Artemisinin |
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| Institution |
| Burnet Institute - Malaria and Infectious Disease Epidemiology Group |
| View Institution website |
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| City |
| Melbourne |
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| Country |
| Australia |
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| Relevant Publications |
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| “Using an improved phagocytosis assay to evaluate the effect of HIV on specific antibodies to pregnancy-associated malaria.” Ataide R, Hasang W, Wilson DW, Beeson JG, Mwapasa V, Molyneux ME, Rogerson, SR, .PLoS ONE. 2010;5(5):e10807. |
| View Publication |
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| “Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.” Ashfaq Ghumra;Pongsak Khunrae;Ricardo Ataide;Ahmed Raza;Stephen J Rogerson;Matthew K Higgins;Alex Rowe, PloS ONE. 2010 |
| View Publication |
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Induction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites.
Ghumra A, Semblat JP, Ataide R, Kifude C, Adams Y, Claessens A, Anong DN, Bull PC, Fennell C, Arman M, Amambua-Ngwa A, Walther M, Conway DJ, Kassambara L, Doumbo OK, Raza A, Rowe JA. |
| View Publication |
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| “Malaria, primigravidae and antibodies: current knowledge and future perspectives” Ricardo Ataíde, Alfredo Mayor, Stephen J. Rogerson. DOI information: 10.1016/j.pt.2013.12.007. Trends in Parasitology (2014) |
| View Publication |
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| “Host Immunity and the assessment of emerging artemisinin resistance in malaria: a multinational cohort study”, Ricardo Ataide, Elizabeth A. Ashley, Rosanna Powell, Jo-Anne Chan, Michael Malloy, Katherine O’Flaherty, Eizo Takashima, Christine Langer, Takafumi Tsuboi, Arjen M. Dondorp, Nicholas P. Day, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, Md. Abul Faiz, James G. Beeson, Francois Nosten, Julie A. Simpson, Nicholas J. White and Freya J.I. Fowkes, (2017) PNAS |
| View Publication |
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"Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study."
Ataíde R, Powell R, Moore K, McLean A, Phyo AP, Nair S, White M, Anderson TJ, Beeson JG, Simpson JA, Nosten F, Fowkes FJI. (2017) Journal of Infectious Diseases |
| View Publication |
| Publications |
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| - “Genetically Attenuated p36p-deficient Plasmodium berghei sporozoites confer long-lasting protection and partial cross-species immunity” Bruno Douradinha; Melissa R. van Dijk; Ricardo Ataíde; Geert-Jan van Gemert ; Joanne Thompson; Dominique Mazier; Robert Sauerwein; Chris J. Jansen; Andrew P. Waters; Maria M. Mota. Int J Parasitol. 2007 May 21;[Epub ahead of print]; PMID: 17604034 |
| View Publication |
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| “Dissecting in vitro host cell infection by Plasmodium sporozoites using flow cytometry”. Prudencio M, Rodrigues CD, Ataide R, Mota MM. Cellular microbiology. 2008 Jan;10(1):218-24). |
| View Publication |
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| “VEGF promotes malaria-associated acute lung injury in mice.” Epiphanio S, Campos MG, Pamplona A, Carapau D, Pena AC, Ataide R, et al. PLoS pathogens. 2010;6(5):e1000916 |
| View Publication |
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Antibodies That Induce Phagocytosis of Malaria Infected Erythrocytes: Effect of HIV Infection and Correlation with Clinical Outcomes
Ricardo Ataíde1,2*, Victor Mwapasa3,4, Malcolm E. Molyneux3,5, Steven R. Meshnick6, Stephen J. Rogerson1
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| View Publication |
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| González, R., Ataíde, R., Naniche, D., Menéndez, C. & Mayor, A. HIV and malaria interactions: where do we stand? Expert Review of Anti-infective Therapy 10, 153-165 (2012). |
| View Publication |
[more publications]
| More Publications |
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On the pathogenesis of Plasmodium vivax malaria: Perspectives from the Brazilian field.
Costa FT, Lopes SC, Albrecht L, Ataíde R, Siqueira AM, Souza RM, Russell B, Renia L, Marinho CR, Lacerda MV.
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| View Publication |
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R. Ataíde*, R.M. Souza*, J.G. Dombrowski, V. Ippólito, E.H. Aitken, S.N. Valle, et al., Placental Histopathological Changes Associated with Plasmodium vivax Infection during Pregnancy. PLoS Neglected Tropical Diseases. 7 (2013) e2071. PMID 23459254
* authors contributed equally
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| View Publication |
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| “Malaria in pregnancy interacts with and alters the angiogenic profiles of the placenta” Ricardo Ataíde, O. Murillo, J.G. Dombrowski, R.M. Souza, F.A. Lima, G.F.M.C. Lima, A.D. Hristov, S.C.N. Valle, S.M. Di Santi, S. Epiphanio, C.R.F. Marinho. (2015). PLoS Neglected Tropical Diseases |
| View Publication |
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| “Malaria and immunity during pregnancy and postpartum: a tale of two species” Alistair A.R.D. McLean, Ricardo Ataíde, Julie A. Simpson, James G. Beeson, Freya J.I. Fowkes. (2015). Journal of Parasitology |
| View Publication |
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| "Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period" Alistair McLean, Machteld Boel, Rose McGready, Ricardo Ataide, Damien Drew, Takafumi Tsuboi, James Beeson, Francois Nosten, Julie A Simpson, and Freya Fowkes. Scientific Reports (2016) |
| View Publication |
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"Antibody Responses to Plasmodium falciparum and Plasmodium vivax and Prospective Risk of Plasmodium spp. Infection Postpartum."
McLean ARD, Boel M, McGready R, Ataide R, Drew D, Tsuboi T, Beeson JG, Nosten F, Simpson J, Fowkes FJI. (2017) Am J Trop Med Hyg |
| View Publication |
| Last Update |
| 2016-05-02 05:40:11 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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