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Class of 1997
Silva, José
1st Degree
University (1st Degree)
University of Porto
About the PhD
Field of Research
Thesis Title
Heritable silencing mechanisms during mouse development
Neil Brockdorff
Claudio Sunkel
University of Porto (PhD)
Neil Brockdorff, Imperial college (PhD)
United Kingdom
Date of Thesis Defence
After the PhD (Current Situation)
Senior Group Leader
Biology of induced pluripotency
University of Cambridge, Cambridge Stem Cell Institute
View Institution website
United Kingdom

Relevant Publications
Yang J, van Oosten AL, Theunissen TW, Guo G, Silva JC, Smith A. Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell. 2010 Sep 3;7(3):319-28.
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Theunissen TW, van Oosten AL, Castelo-Branco G, Hall J, Smith A, Silva JC. Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol. 2011 Jan 11;21(1):65-71. Epub 2010 Dec 30.
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Theunissen, TW, Costa, Y., Radzhisheuskaya, A., van Oosten, A.L., Lavial, F., Pain, B., Castro, LFC, Silva JCR. Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 2011 Nov;138(22):4853-65.
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van Oosten AL, Costa Y, Smith A, Silva JCR. Jak/Stat3 signalling is sufficient and dominant over antagonistic cues for the establishment of naďve pluripotency. Nature Communications. May 8;3:827 (2012) doi: 10.1038/ncomms1822.
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Radzisheuskaya A, Pasque V, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA, Silva JCR. Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. Journal of Cell Science. Oct 17, (2012) doi: 10.1242/​jcs.113019.
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Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, Fidalgo M, Saunders A, Lawrence M, Dietmann S, Das S ,Levasseur DN, Li Z, Xu M, Reik W, Wang J#, Silva JCR#. Nanog-dependent function of Tet1 and Tet2 in establishment of pluripotency. Nature. (2013), doi:10.1038/nature11925.
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Radzisheuskaya A, Chia GLB, Santos R, Theunissen TW, Castro LFC, Nichols J, Silva JCR. A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages. Nature Cell Biology. 30 April (2013) doi:10.1038/ncb2742
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Silva J, Smith A. Capturing pluripotency. Cell, 2008 February 22; 132(4):532-6.
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Chambers I, Silva J, Colby D, Nichols J, Robertson M, Nijmeijer B, Vrana J, Grotewold L, Smith A. Nanog safeguards pluripotency and mediates germline development. Nature. 2007 Dec 20;450(7173):1230-4.
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Silva J, Chambers I, Pollard S, Smith A. Nanog promotes transfer of pluripotency after cell fusion. Nature. 2006 Jun 22;441(7096):997-1001. Epub 2006 Jun 14.
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Silva J, Mak W, Zvetkova I, Appanah R, Nesterova TB, Webster Z, Peters AH, Jenuwein T, Otte AP, Brockdorff N. Establishment of histone H3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Developmental Cell. 2003 Apr;4(4):481-95.
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Silva J#, Nichols J, Theunissen TW, Guo G, van Oosten AL, Barrandon O, Wray J, Yamanaka S, Chambers I, Smith A#. Nanog is the gateway to the pluripotent ground state. Cell. 2009 Aug 21;138(4):722-37.
(#joint corresponding authors)
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Silva J*, Barrandon O, Nichols J, Theunissen TW, Kawaguchi J, Smith A*. Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition. PLoS Biology. 2008 doi:10.1371/journal.pbio.0060253.
(* joint corresponding authors)
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Buehr M, Meek S, Blair K, Yang J, Ure J, Silva J, McLay R, Hall J, Ying Q, Smith A. Capture of Authentic Embryonic Stem Cells from Rat Blastocysts. Cell. 2008 Dec 26;135(7):1287-98.
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Silva J, Nichols J, Roode M, Smith A. Suppression of Erk signaling promotes ground state pluripotency in the mouse embryo. Development. 2009 doi:10.1242/dev.038893.
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Mak W, Baxter J, Silva J, Newall AE, Otte AP, Brockdorff N. Mitotically stable association of polycomb group proteins eed and enx1 with the inactive x chromosome in trophoblast stem cells. Curr Biol. 2002 Jun 25;12(12):1016-20.
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Theunissen TW, Silva JC. Switching on pluripotency: a perspective on the biological requirement of Nanog. Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2222-9.
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Fidalgo M, Faiola F, Pereira CF, Ding J, Saunders A, Gingold J, Schaniel C, Lemischka IR, Silva JCR, Wang J. Zfp281 Mediates Nanog Autorepression through Recruitment of the NuRD Complex and Inhibits Somatic Cell Reprogramming. Proc Natl Acad Sci. (2012) Oct 2;109(40):16202-7. doi: 10.1073/pnas.1208533109. Epub 2012 Sep 17.
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de Napoles M, Mermoud JE, Wakao R, Tang YA, Endoh M, Appanah R, Nesterova TB, Silva J, Otte AP, Vidal M, Koseki H, Brockdorff N. Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Developmental Cell. 2004 Nov;7(5):663-76.
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Banito A, Rashid ST, Acosta JC, Li S, Pereira CF, Geti I, Pinho S, Silva JC, Azuara V, Walsh M, Vallier L, Gil J. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 2009 doi:10.1101/gad.1811609
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Last Update
2017-10-13 15:31:42

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