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Class of 2009
Name
Rei, Margarida
Nationality
Portuguese
E-Mail
margaridarei@gmail.com
1st Degree
Applied Biology
University (1st Degree)
Universidade do Minho
About the PhD
Field of Research
Cancer Immunology
Thesis Title
Characterization of a pro-tumour role of interleukin-17-producing gammadelta T cells in ovarian cancer
Abstract
Cancer-associated inflammation mobilizes a variety of leukocyte populations that can inhibit or enhance tumour cell growth in situ. These subsets include gammadelta T cells, which can infiltrate tumours and typically provide...
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Supervisor(s)
Bruno Silva-Santos, Daniel Pennington
Co-Supervisor(s)
Rui Appelberg
University
ICBAS - Instituto de Ciencias Biomedicas de Abel Salazar
Laboratory
Molecular Immunology Unit, Instituto de Medicina Molecular, Universidade de Lisboa & Centre for Immunology and Infectious Diseases, Barts and The London Medical School, Queen Mary University of London
Date of Thesis Defence
2014-12-17
After the PhD (Current Situation)
Position
Postdoctoral Scientist
Institution
Wheatherall Institute of Molecular Medicine
View Institution website
City
Oxford
Country
UK

Relevant Publications
Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ, Silva-Santos B. Murine CD27(−) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. PNAS. 2014 Aug 26;111(34):E3562-70
View Publication
Rei M, Pennington DJ, Silva-Santos B. The emerging protumor role of γδ T lymphocytes: implications for cancer immunotherapy. Cancer Research 2015 Mar 1; 75(5):798-802

Publications
Lança T, Costa MF, Gonçalves-Sousa N, Rei M, Grosso AR, Penido C, Silva-Santos B. Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic γδ T lymphocytes to tumor beds. J Immunol. 2013 Jun 15;190(12):6673-80
View Publication
Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B. Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat Immunol. 2013 Oct;14(10):1093-100
View Publication
Last Update
2015-02-07 19:14:55

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