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| Name |
| Sin, Olga |
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| Nationality |
| Portuguese |
| E-Mail |
| olga.sin@mpi-muenster.mpg.de |
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| 1st Degree |
| Cellular and Molecular Biology |
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| University (1st Degree) |
| Universidade Nova de Lisboa |
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| Master Degree |
| Neurosciences |
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| University (Master Degree) |
| Universidade de Lisboa |
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| About the PhD |
| Field of Research |
| Neurosciences |
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| Thesis Title |
| Aggregation-promoting factors in neurodegenerative diseases: Insights from a C. elegans model |
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| Abstract |
| Neurodegenerative diseases are complex human diseases that are still poorly understood in terms of their etiology and pathogenesis. The objective of this work is to zoom in on the molecular and cellular events that lead to... |
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| Neurodegenerative diseases are complex human diseases that are still poorly understood in terms of their etiology and pathogenesis. The objective of this work is to zoom in on the molecular and cellular events that lead to a distinctive characteristic shared by several neurodegenerative diseases: protein aggregation. We take advantage of the nematode Caenorhabditis elegans (C. elegans) to discover genes that modify protein aggregation and toxicity (proteotoxicity) and to further examine how these genes contribute to the aggregation process. In addition, we aim to validate our observations in the mammalian system, by testing whether the mammalian orthologs of the new genes have similar effects on protein aggregation. Ultimately, we hope that the discovery of these modifiers will add to insights in the field, thereby providing a better understanding of how the aggregation process works, which cellular functions are involved and, importantly, how these are affected in the context of disease. |
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| Supervisor(s) |
| Prof. Dr. Ellen Nollen; Dr. Victor Guryev |
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| Co-Supervisor(s) |
| Prof. Dr. João Bettencourt Relvas |
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| University |
| University Medical Center Groningen, The Netherlands and Instituto de Ciências Biomédicas de Abel Salazar, Portugal |
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| City |
| Groningen |
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| Country |
| The Netherlands |
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| Date of Thesis Defence |
| 2016-01-13 |
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| After the PhD (Current Situation) |
| Position |
| Marie-Sklodowska Curie Postdoctoral Fellow |
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| Project |
| Elucidating the role of transfer RNAs in protein quality control |
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| Institution |
| Max Planck Institute for Molecular Biomedicine |
| View Institution website |
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| City |
| Münster |
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| Country |
| Germany |
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| Relevant Publications |
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| Olga Sin, Tristan de Jong, Alejandro Mata-Cabana, Michelle Kudron, Mohamad Amr Zaini, Francesco A. Aprile, Renée I. Seinstra, Esther Stroo, Roméo Willinge Prins, Céline N. Martineau, Hai Hui Wang, Wytse Hogewerf, Anne Steinhof, Erich E. Wanker, Michele Vendruscolo, Cornelis F. Calkhoven, Valerie Reinke, Victor Guryev, and Ellen A.A. Nollen. 2017 Molecular Cell 65, 1096–1108. |
| View Publication |
| Publications |
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| Sin O, Michels H, Nollen EAA. Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases. Biochim Biophys Acta. 2014 Oct;1842(10):1951-1959. doi: 10.1016/j.bbadis.2014.01.015. Epub 2014 Feb 11. |
| View Publication |
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| Sin O and Nollen EAA. Regulation of protein homeostasis in aging and aging-related diseases: role of coding and non-coding genes. Cell Mol Life Sci. 2015 Nov;72(21):4027-47. doi: 10.1007/s00018-015-1985-0. Epub 2015 Jul 21. |
| View Publication |
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| Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak K, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Büttner R, Marine JC, Chariot A, Close P. Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature. 2018 558(7711):605-609. |
| View Publication |
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| Rode S, Ohm H, Anhäuser L, Wagner M, Rosing M, Deng X, Sin O, Leidel SA, Storkebaum E, Rentmeister A, Zhu S, Rumpf S. Differential Requirement for Translation Initiation Factor Pathways During Ecdysone-Dependent Neuronal Remodeling in the Drosophila PNS. Cell Reports. 2018 24:2287–2299 |
| View Publication |
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| Sin O, Mata-Cabana A, Seinstra RI, Nollen EAA. Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates. Bio-protocol. 2018 8(19): e3042. DOI: 10.21769/BioProtoc.3042 |
| View Publication |
[more publications]
| More Publications |
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| Mata-Cabana A, Sin O, Seinstra RI, Nollen EAA. Nuclear/cytoplasmic Fractionation of Proteins from Caenorhabditis elegans. Bio-protocol. 2018 Bio-protocol 8(20): e3053. DOI: 10.21769/BioProtoc.3053 |
| View Publication |
| Last Update |
| 2018-12-02 16:02:27 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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