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Class of 2011
Name
Arezes, João
Nationality
Portuguese
E-Mail
jtarezes@gmail.com
1st Degree
Biochemistry
University (1st Degree)
Porto
Master Degree
Biochemistry
University (Master Degree)
Porto
About the PhD
Field of Research
Iron Biology / Infection
Thesis Title
The role of hepcidin in host defense against Vibrio vulnificus infections
Abstract
Hereditary hemochromatosis, an iron overload disease caused by a deficiency in the iron-regulatory hormone hepcidin, is associated with lethal infections by siderophilic bacteria. To elucidate the mechanisms of this susceptibility,...
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Supervisor(s)
Elizabeta Nemeth, PhD
Co-Supervisor(s)
Tomas Ganz, MD, PhD; Graça Porto, MD, PhD
University
University of California, Los Angeles
City
Los Angeles
Country
USA
Date of Thesis Defence
2015-11-20
After the PhD (Current Situation)
Position
Postdoctoral Scientist
Institution
Weatherall Institute of Molecular Medicine, University of Oxford
View Institution website
City
Oxford
Country
United kingdom

Relevant Publications
Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus, Cell Host & Microbe, 2015, 17, 47-57
View Publication

Publications
Non-Transferrin-Bound Iron (NTBI) Uptake by T Lymphocytes: Evidence for the Selective Aquisition of Oligomeric Ferric Citrate Species, PLOS One, 2013, 8(11):e79870
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Physiological implications of NTBI uptake by T lymphocytes, Frontiers in Pharmacology, 2014, 5:24
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Hepcidin and iron disorders: new biology and clinical approaches, International Journal of Laboratory Hematology, 2015,
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Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non–transferrin-bound iron, Blood 2017 130:245-257
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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3, Nature Communications 8, Article number: 403 (2017)
View Publication
Last Update
2017-10-11 16:01:44

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INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology