|
|
|
| Name |
| De Jesus, Dário F. |
|
| Nationality |
| Portuguese |
| E-Mail |
| dario_lucio_jesus@hotmail.com |
|
| 1st Degree |
| Biology |
|
| University (1st Degree) |
| UTAD - University of Trás-os-Montes and Alto Douro / University Babeş-Bolyai |
|
| Master Degree |
| Clinical and Laboratory Biology |
|
| University (Master Degree) |
| UTAD - University of Trás-os-Montes and Alto Douro / Joslin Diabetes Center - Harvard Medical School |
|
| About the PhD |
| Field of Research |
| Health / Diabetes / Obesity / Metabolism / Epigenetics |
|
| Thesis Title |
| INVESTIGATING EPIGENETIC REPROGRAMING MECHANISMS IN THE OFFSPRING OF A NON-DIETARY MODEL OF INSULIN RESISTANCE |
|
| Abstract |
| As progression to Type 2 diabetes (T2D) is largely due to insulin secretory dysfunction and significant beta-cell loss, further research in understanding the epigenetic modifications in offspring beta-cells of insulin resistant... |
| more |
| As progression to Type 2 diabetes (T2D) is largely due to insulin secretory dysfunction and significant beta-cell loss, further research in understanding the epigenetic modifications in offspring beta-cells of insulin resistant parents, might play an important role in determining how elevated levels of insulin and glucose itself, influences the expression of important genes in betacell function and survival. Moreover this approach might be useful to design strategies to restore the DNA methylation patterns, promoting beta-cell survival, mass and function, thereby preventing and treating T2D. |
| close |
|
|
| Supervisor(s) |
| Rohit Kulkarni, MD, PhD |
|
| Co-Supervisor(s) |
| Carmén Jerónimo, PhD; Amélia M Silva, PhD |
|
| University |
| Harvard Medical School |
|
| Laboratory |
| Joslin DIabetes Center - Kulkarni Lab |
|
| City |
| Boston |
|
| Country |
| USA |
|
| Date of Thesis Defence |
| 2019-03-06 |
|
|
| Relevant Publications |
|
| De Jesus DF, Kulkarni RN. Epigenetic modifiers of islet function and mass. TEM 25(12): 628-636, 2014 |
| View Publication |
| Publications |
|
| Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo A, Hu J, Kawamori D, Gaglia J, Mathis D, Kulkarni RN. Soluble factors secreted by T-cells promote β-cell proliferation. Diabetes 63:188-202, 2014. |
| View Publication |
|
| Dirice E, Kahraman S, De Jesus DF, Hu J, Kulkarni RN. Maternal insulin resistance and transient hyperglycemia impacts the metabolic and endocrine phenotypes of offspring. APJ - Endocrinology and Metabolism DOI: 10.1152/ajpendo.00210.2014, 2014. |
| View Publication |
|
| El Ouaamari A, Zhou J, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus D, Bhatt S, Kim JS, Clauss TRW, Camp DG, Smith RD, Qian WJ and Kulkarni RN. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J. Proteome Res 14(8):3111-22, 2015 |
| View Publication |
|
| Gupta MK, Teo AKK, Rao TN, Bhatt S, Kleinridders A, Shirakawa, J, Takatani T, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN. Excessive cellular proliferation negatively impacts reprogramming efficiency of human fibroblasts. Stem Cells Trans Med DOI: 10.5966/sctm.2014-0217. |
| View Publication |
| Last Update |
| 2014-07-23 18:45:40 |
| The responsibility for this page contents is entirely of the student/alumnus. |
|
 |
|
 |
|
 |
|
 |
|
 |
|
 |
|
Program financially supported by
the National Foundation for
Science and Technology
|
|
 |
|
