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Class of 2011
Name
De Jesus, Dário F.
Nationality
Portuguese
E-Mail
dario_lucio_jesus@hotmail.com
1st Degree
Biology
University (1st Degree)
UTAD - University of Trás-os-Montes and Alto Douro / University Babeş-Bolyai
Master Degree
Clinical and Laboratory Biology
University (Master Degree)
UTAD - University of Trás-os-Montes and Alto Douro / Joslin Diabetes Center - Harvard Medical School
About the PhD
Field of Research
Health / Diabetes / Obesity / Metabolism / Epigenetics
Thesis Title
INVESTIGATING EPIGENETIC REPROGRAMING MECHANISMS IN THE OFFSPRING OF A NON-DIETARY MODEL OF INSULIN RESISTANCE
Abstract
As progression to Type 2 diabetes (T2D) is largely due to insulin secretory dysfunction and significant beta-cell loss, further research in understanding the epigenetic modifications in offspring beta-cells of insulin resistant...
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Supervisor(s)
Rohit Kulkarni, MD, PhD
Co-Supervisor(s)
Carmén Jerónimo, PhD; Amélia M Silva, PhD
University
Harvard Medical School
Laboratory
Joslin DIabetes Center - Kulkarni Lab
City
Boston
Country
USA

Relevant Publications
De Jesus DF, Kulkarni RN. Epigenetic modifiers of islet function and mass. TEM 25(12): 628-636, 2014
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Publications
Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus DF, Teo A, Hu J, Kawamori D, Gaglia J, Mathis D, Kulkarni RN. Soluble factors secreted by T-cells promote β-cell proliferation. Diabetes 63:188-202, 2014.
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Dirice E, Kahraman S, De Jesus DF, Hu J, Kulkarni RN. Maternal insulin resistance and transient hyperglycemia impacts the metabolic and endocrine phenotypes of offspring. APJ - Endocrinology and Metabolism DOI: 10.1152/ajpendo.00210.2014, 2014.
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El Ouaamari A, Zhou J, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus D, Bhatt S, Kim JS, Clauss TRW, Camp DG, Smith RD, Qian WJ and Kulkarni RN. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J. Proteome Res 14(8):3111-22, 2015
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Gupta MK, Teo AKK, Rao TN, Bhatt S, Kleinridders A, Shirakawa, J, Takatani T, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni RN. Excessive cellular proliferation negatively impacts reprogramming efficiency of human fibroblasts. Stem Cells Trans Med DOI: 10.5966/sctm.2014-0217.
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Last Update
2014-07-23 18:45:40
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology