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| Name |
| Duarte, Delfim |
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| Nationality |
| Portuguese |
| E-Mail |
| delfimd@med.up.pt |
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| Master Degree |
| Medicine |
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| University (Master Degree) |
| University of Porto |
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| About the PhD |
| Field of Research |
| Leukemia, microenvironment, intravital microscopy |
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| Thesis Title |
| In vivo imaging of the dynamic interactions of acute leukaemias with the bone marrow microenvironment |
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| Abstract |
| It has been hypothesized that haematopoietic stem cells (HSC) residing in the bone marrow (BM) receive survival and differentiation signals from a range of cell types including osteoblasts and endothelial cells. In parallel,... |
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It has been hypothesized that haematopoietic stem cells (HSC) residing in the bone marrow (BM) receive survival and differentiation signals from a range of cell types including osteoblasts and endothelial cells. In parallel, cancer growth and chemo-resistance have been proposed to be dependent on a malignant microenvironment. However, to date therapeutics targeting the BM stroma in cancer have not been effective. Thus, there is an urgency to better understand the role of the microenvironment in cancer progression, response to treatment and relapse, particularly in aggressive cancers, such as acute leukaemias.
Using intravital confocal and 2-photon microscopy of the mouse calvarium BM, I am exploring the role of the BM microenvironment in the context of T-cell acute lymphoblastic leukaemia (T-ALL) and acute myeloid leukaemia (AML). |
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| Supervisor(s) |
| Cristina Lo Celso |
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| University |
| Imperial College London / The Francis Crick Institute |
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| City |
| London |
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| Country |
| UK |
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| Date of Thesis Defence |
| 2018-05-08 |
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| After the PhD (Current Situation) |
| Position |
| Physician-scientist |
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| Project |
| Leukemia and bone marrow microenvironment |
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| Institution |
| i3S / UP / IPO-Porto |
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| City |
| Porto |
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| Country |
| Portugal |
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| Relevant Publications |
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| T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments. Hawkins ED*, Duarte D* et al. Nature. 2016 Oct 27;538(7626):518-522. (*equal contribution) |
| View Publication |
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| Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML. Duarte D et al. Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6. |
| View Publication |
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| The interplay of leukemia cells and the bone marrow microenvironment. Duarte D, Hawkins ED, Lo Celso C. Blood. 2018 Apr 5;131(14):1507-1511. |
| Publications |
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| Angiogenesis and inflammation signalling are targets of beer polyphenols on vascular cells. Negrão R, Costa R, Duarte D, Taveira Gomes T, Mendanha M, Moura L, Vasques L, Azevedo I, Soares R. J Cell Biochem. 2010 Dec 1;111(5):1270-9. |
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| Could platelet-accumulating polyphenols prevent tumour metastasis? Negrão R, Duarte D, Costa R, Soares R. Nat Rev Cancer. 2011 Aug 24; 11(9):685 (letter to the Editor). |
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| Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes. Negrão R, Costa R, Duarte D, Gomes TT, Coelho P, Guimarães JT, Guardão L, Azevedo I, Soares R. J Cell Biochem. 2012 Jan;113(1):100-9. |
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| Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers. Kural C, Tacheva-Grigorova SK, Boulant S, Cocucci E, Baust T, Duarte D, Kirchhausen T. Cell Rep. 2012 Oct 24 |
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| Increased circulating platelet microparticles as a potential biomarker in asthma. Duarte D*, Taveira-Gomes T, Sokhatska O, Palmares C, Costa R, Negrão R, Guimarães JT, Delgado L, Soares R, Moreira A. Allergy. 2013 Aug;68(8):1073-5. (*corresponding author) |
[more publications]
| More Publications |
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| Isoxanthohumol modulates angiogenesis and inflammation via vascular endothelial growth factor receptor, tumor necrosis factor alpha and nuclear factor kappa B pathways. Negrão R*, Duarte D*, Costa R, Soares R. Biofactors. 2013 Aug 1 (*equal contribution) |
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| Automated Identification and Localization of Hematopoietic Stem Cells in 3D Intravital Microscopy Data. Khorshed RA, Hawkins ED, Duarte D, Scott MK, Akinduro OA, Rashidi NM, Spitaler M, Lo Celso C. Stem Cell Reports. 2015 Jul 14;5(1):139-53 |
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| Duarte, D., and Lo Celso, C. (2017). Imaging the Hematopoietic Stem Cell Niche. Advances in Stem Cells and their Niches 1, 59-83. (book chapter) |
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| The passive biomechanics of human pelvic collecting lymphatic vessels. Athanasiou D, Edgar LT, Jafarnejad M, Nixon K, Duarte D et al. PLoS One. 2017 Aug 21;12(8):e0183222. |
| Last Update |
| 2018-06-19 18:01:26 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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