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| Name |
| Soares da Silva, Francisca |
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| Nationality |
| Portuguese |
| E-Mail |
| fcg.soaresdasilva@gmail.com |
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| 1st Degree |
| Biomedical Pharmacy |
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| University (1st Degree) |
| Coimbra |
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| Master Degree |
| Biomedical Research |
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| University (Master Degree) |
| Coimbra |
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| About the PhD |
| Field of Research |
| Developmental Biology & Immunology |
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| Thesis Title |
| Environmental Signals Driving the Onset of Hematopoiesis in the Fetal Liver |
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| Abstract |
| Hematopoiesis occurs in specialized organs and the role of the environment in the behavior of hematopoietic progenitors is increasingly recognized. There is compelling evidence that the major hematopoietic supportive stromal... |
| more |
| Hematopoiesis occurs in specialized organs and the role of the environment in the behavior of hematopoietic progenitors is increasingly recognized. There is compelling evidence that the major hematopoietic supportive stromal elements in the bone marrow (BM) are endothelial cells and mesenchymal cells of the osteoblast and adipocyte lineage. In contrast, very little information exists on the stromal compartment in fetal liver (FL). The FL is the major hematopoietic organ during embryonic development and the only site where hematopoietic stem cells (HSC) expand. The specific aims of this PhD proposal are: (i) to isolate and to characterize in FL the stromal compartment driving the development of the definitive hematopoietic system; (ii) to identify the environmental signals that fine-tune self-renewal vs. differentiation of HSC. Identification and characterization of the stromal compartment in FL will allow a better understanding of the molecular cues underlying the expansion of HSC and thus the design of more efficient strategies for obtaining large numbers of HSC ex vivo and more flexibility in their manipulation, in gene therapy protocols, and in defining conditions for developing HSC from embryonic or induced pluripotent stem cells. The fundamental knowledge, the products and the assays resulting from this project will impact on the clinical practice of hematopoietic transplantation. |
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| Supervisor(s) |
| Perpétua Pinto-do-Ó & Ana Cumano |
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| University |
| ICBAS |
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| Laboratory |
| INEB/i3S, Porto, Portugal & Institut Pasteur, Paris, France |
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| Date of Thesis Defence |
| 2021-03-22 |
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| Relevant Publications |
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| Soares-da-Silva Francisca*, Peixoto Márcia*, Cumano Ana, Pinto-do-Ó Perpetua. Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Development 2020 Frontiers in Cell and Developmental Biology doi: 10.3389/fcell.2020.00612 |
| View Publication |
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| Elsaid Ramy*, Soares-da-Silva Francisca*, Peixoto Marcia, Amiri Dali, Mackowski Nathan, Pereira Pablo, Bandeira Antonio, Cumano Ana. Hematopoiesis: A Layered Organization Across Chordate Species 2020 Frontiers in Cell and Developmental Biology doi:10.3389/fcell.2020.606642 |
| View Publication |
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| Soares-da-Silva F, Freyer L, Elsaid R, Burlen-Defranoux O, Iturri L, Sismeiro O, Pinto-do-Ó P, Gomez-Perdiguero E, Cumano A. Yolk sac, but not HSC-derived progenitors, sustain erythropoiesis throughout murine embryonic life 2021 J. Exp. Medicine. 218(4); doi: 10.1084/jem.20201729 |
| View Publication |
| Publications |
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| Freire AG, Waghray A, Soares-da-Silva F, Resende TP, Lee DF, Pereira CF, Nascimento DS, Lemischka IR, and Pinto-do-Ó P. (2017) Transient HES5 activity instructs mesodermal cells toward a cardiac fate. Stem Cell Reports. 9(1), 136-148. |
| View Publication |
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| Valente M, Resende TP, Nascimento DS, Burlen-Defranoux O, Soares-da-Silva F, et al. (2019) Mouse HSA+ immature cardiomyocytes persist in the adult heart and expand after ischemic injury. PLOS Biology 17(6): e3000335. https://doi.org/10.1371/journal.pbio.3000335 |
| View Publication |
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| Ramy Elsaid, Sylvain Meunier, Odile Burlen-Defranoux, Francisca Soares-da-Silva, Thibaut Perchet, Lorea Iturri, Laina Freyer, Paulo Vieira, Pablo Pereira, Rachel Golub, Antonio Bandeira, Elisa Gomez Perdiguero, Ana Cumano; A wave of bipotent T/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner. Blood blood.2020006779. |
| View Publication |
| Last Update |
| 2020-12-21 10:47:39 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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