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Class of 2015
Name
Silva, Miguel
Nationality
Portuguese
E-Mail
gsilva.miguel@gmail.com
1st Degree
Biology
University (1st Degree)
Porto
Master Degree
Oncology
University (Master Degree)
Porto
About the PhD
Field of Research
Cancer Research
Thesis Title
PiggyBac transposon-based genetic screening in mice to uncover molecular networks of Braf V600E-induced intestinaltumourigenesis
Abstract
BRAF-mutantcolorectalcancersformalargetumoursubsetwithdistinctivemorphologic,geneticandclinicalcharacteristics.Themolecularevolutionofthesecancersishoweverpoorlyunderstood.Wedevelopedaconditional(Cre-orSleepingBeautyactivatable)BrafV600Eknock-inmouselineandfoundthatmutantBrafinitiatesanovelpathwaytointestinalcancer,whichprogressesthroughahyperplasia/adenoma/carcinomasequencemimickingkeygeneticandmorphologiccharacteristicsofthehumancondition.ToovercomethelimitationsinherenttoexomesequencingofthesetumorswedevelopedaPiggyBactransposon-basedcancergenediscovertool-kitinmice,whichenablesunbiasedgeneticscreeninginvivo.Usingthisapproachrelevantpathwaysorpathwaybranchesare“hit”bytransposonsatmultiplelevelsandthetransposonintegrationpatternpredictsthegene’sfunctionasoncogenicortumoursuppressive.First,weaimtoperformPiggyBac...
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Supervisor(s)
Prof. Dr. Roland Rad
Co-Supervisor(s)
Dr. José Luis Costa
University
Technische Universität München (TUM)
Laboratory
AG Rad
City
Munich
Country
Germany
Date of Thesis Defence
2022-05-09
Last Update
2017-10-06 14:25:30

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INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology