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| Name |
| Preto, Ana |
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| Nationality |
| Portuguese |
| E-Mail |
| apreto@bio.uminho.pt |
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| 1st Degree |
| Pharmaceutical Sciences |
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| University (1st Degree) |
| University of Porto |
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| About the PhD |
| Field of Research |
| Oncobiology |
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| Thesis Title |
| IDENTIFICATION OF POTENTIAL MECHANISMS OF TOLERANCE TO WILD-TYPE P53 IN HUMAN CARCINOGENESIS USING THYROID NEOPLASIA AS A PROTOTYPE |
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| Supervisor(s) |
| Professor Manuel Sobrinho-Simões |
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| Co-Supervisor(s) |
| Doctor Christopher Jones |
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| University |
| University of Porto and University of Wales College of Medicine |
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| Laboratory |
| IPATIMUP |
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| City |
| Porto |
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| Country |
| Portugal |
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| Date of Thesis Defence |
| 2004-01-30 |
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| After the PhD (Current Situation) |
| Position |
| Assistant Professor at the Department of Biology, Researcher at CBMA |
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| Project |
| Oncobiology and Nanomedicine |
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| Institution |
| Department of Biology, CBMA, University of Minho |
| View Institution website |
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| City |
| Braga |
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| Country |
| Portugal |
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| Relevant Publications |
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| Marques C, Oliveira CSF, Alves S, Chaves SR, Coutinho OP, Côrte-Real M, Preto A. “Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release”. Cell Death and Disease (2013) Feb 21;4:e507. doi: 10.1038/cddis.2013.29. |
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João Azevedo-Silva, Odilia Queirós, Fatima Baltazar, Young H. KO, Peter Pedersen, Ana Preto, Margarida Casal. “The cytotoxicity of 3-Bromopyruvate in breast cancer cells depends on extracellular pH”. Biochem J. 2015 Apr 15;467(2):247-58.
doi: 10.1042/BJ20140921. |
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| Oliveira CSF, Pereira H, Alves S, Castro L, Baltazar F, Chaves SR, Côrte-Real M, Preto A."Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria". Cell Death Dis. 2015 Jun 18;6:e1788. doi: 10.1038/cddis.2015.157. |
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Amorim R, Pinheiro C, Miranda-Gonçalves V, Pereira H, Moyer MP, Preto A, Baltazar F. “Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells.” Cancer Lett. 2015 Aug 28;365(1):68-78.
doi: 10.1016/j.canlet.2015.05.015. |
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Alves S, Castro L, Fernandes MS, Francisco R, Castro P, Priault M, Chaves SR, Moyer MP, Oliveira C, Seruca R, Côrte-Real M, Sousa MJ, Preto A. “Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy”. Oncotarget. 2015 Oct 13;6(31):30787-802. doi: 10.18632/oncotarget.5021. |
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Eugénia Nogueira, Franck Lager, Delphine Le Roux, Patrícia Nogueira, Jaime Freitas, Celine Charvet, Gilles Renault, Ana Loureiro, Catarina R. Almeida, Anna Ohradanova-Repic, Christian Machacek, Gonçalo J. L. Bernardes, Alexandra Moreira, Hannes Stockinger, Michael Burnet, Alexandre M. Carmo, Andreia C. Gomes, Ana Preto, Georges Bismuth and Artur Cavaco-Paulo. "Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice." Journal of Biomedical Nanotechnology, 2015, 11(12), 2243-2252.
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| Nogueira E., MangialavoriI. C., Loureiro A., Azoia N. G., Sárria M. P., Nogueira P., Freitas J., Harmark, J., Shimanovich U., Rollett A., Lacroix G., Bernardes G. J. L., Guebitz G., Hebert H., Moreira A., Carmo A. M., Rossi J. P. F. C., Gomes A. C., Preto A. and Cavaco-Paulo A. “Peptide anchor for folate-targeted liposomal delivery”. Biomacromolecules, 2015, 16(9), 2904-2910. |
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| Eugénia Nogueira, Andreia Gomes, Ana Preto and Artur Cavaco-Paulo. “Design of Liposomal Formulations for Cell Targeting”. Colloids Surf B Biointerfaces. 2015 Dec 1;136:514-26. doi: 10.1016/j.colsurfb.2015.09.034. |
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| Eugénia Nogueira, Andreia Gomes, Ana Preto and Artur Cavaco-Paulo. “Folate-targeted nanoparticles for rheumatoid arthritis therapy.” Nanomedicine. 2015 Dec 28. pii: S1549-9634(15)00610-3. doi: 10.1016/j.nano.2015.12.365. |
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| Nogueira E, Cruz CF, Loureiro A, Nogueira P, Freitas J, Moreira A, Carmo AM, Gomes AC, Preto A, Cavaco-Paulo A.. “Assessment of nanocapsule disruption to drug delivery in vitro”. Biochim Biophys Acta. 2016 Feb;1858(2):163-7. doi: 10.1016/j.bbamem.2015.11.008. |
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| Azevedo-Silva J., Ko Y. H., Pedersen P. L., Preto A., Casal M. “Anticancer agent 3BP: license to kill. “3-Bromopyruvate: from a simple molecule to the bedside of oncology patients”. J Bioenerg Biomembr. 2016 Aug;48(4):349-62. doi: 10.1007/s10863-016-9670-z |
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| Ferro S, Azevedo-Silva J, Casal M, Côrte-Real M, Baltazar F, Preto A. “Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications”, Oncotarget. 2016 Sep 21. doi: 10.18632/oncotarget.12156. |
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Giulia Cazanelli, Suellen Ferro, Tiago Moreira, João Silva, Eugenia Nogueira, Ana Preto. Colorectal cancer therapeutic approaches: from classical drugs to new nanoparticles. Frontiers in Anti-Cancer Drug Discovery, 2016, Vol7, 3-82. Chapter3. Bentham eBooks, Bentham Science Publishers. |
| Publications |
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| Queirós O, Preto A, Pacheco A, Pinheiro C, Silva J, Moreira R, Pedro M, Ko Y, Pederson P, Baltazar F and Casal M. “Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate”. J Bioenerg Biomembr 2012, 44(1):141-53. http://hdl.handle.net/1822/21366 |
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| Nogueira E, Loureiro A, Nogueira P, Freitas J, R. Almeida CR, Härmark J, Hebert H, Moreira A, Carmo AM, Preto A, Gomes AC, Cavaco-Paulo A. “Liposome and protein based stealth nanoparticles”. Faraday Discussions 2013, DOI: 10.1039/C3FD00057E |
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| Baltazar F, Pinheiro C, Morais-Santos F, Azevedo-Silva J, Queirós O, Preto A, Casal M. “Monocarboxylate transporters as targets and mediators in cancer therapy response”. Histol Histopathol. 2014 Dec;29(12):1511-1524. Epub 2014 Jun 12. |
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| Ana Loureiro, Gonçalo J. L. Bernardesc, Ulyana Shimanovichc, Marisa Passos Sárriaa,b, Eugénia Nogueira, Ana Preto, Andreia C. Gomesb, Artur Cavaco-Paulo. “Folic Acid-Tagged Protein Nanoemulsions Loaded with CORM-2 Enhance the Survival of Mice Bearing Subcutaneous A20 Lymphoma Tumors”, Nanomedicine. 2015 Jul;11(5):1077-83. doi: 10.1016/j.nano.2015.02.022. |
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| Ana Loureiro, Eugénia Nogueira, Nuno G. Azoia, Marisa Passos Sárria, Ana Sofia Abreu, Ulyana Shimanovich, Alexandra Rollett, Johan Härmark, Hans Hebert, Georg Guebitz, Gonçalo J. L. Bernardes, Ana Preto, Andreia C. Gomes, Artur Cavaco-Paulo. “Size Controlled Protein Nanoemulsions for Active Targeting of Folate Receptor Positive Cells”. Colloids and Surfaces B: Biointerfaces, 2015, 135, 90-98. doi:10.1016/j.colsurfb.2015.06.073 |
[more publications]
| More Publications |
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| Nogueira E, Gomes AC, Preto A, Cavaco-Paulo A. “Folate-targeted nanoparticles for rheumatoid arthritis therapy”. Nanomedicine. 2016 May;12(4):1113-26. doi: 10.1016/j.nano.2015.12.365. |
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Nogueira E., Gomes A. C., Preto A. and Cavaco-Paulo A. “Update on therapeutic approaches for rheumatoid arthritis.” Curr Med Chem. 2016;23(21):2190-203.
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| Nogueira E, Freitas J, Loureiro A, Nogueira P, Gomes AC, Preto A, Carmo AM, Moreira A, Cavaco-Paulo A. Neutral PEGylated liposomal formulation for efficient folate-mediated delivery of MCL1 siRNA to activated macrophages. Colloids Surf B Biointerfaces. 2017 Jul 1;155:459-465. doi: 10.1016/j.colsurfb.2017.04.023. |
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| Ohradanova-Repic A, Nogueira E, Hartl I, Gomes AC, Preto A, Steinhuber E, Mühlgrabner V, Repic M, Kuttke M, Zwirzitz A, Prouza M, Suchanek M, Wozniak-Knopp G, Horejsi V, Schabbauer G, Cavaco-Paulo A, Stockinger H. “Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells”. Nanomedicine. 2017 Sep 19. pii: S1549-9634(17)30170-3. doi: 10.1016/j.nano.2017.09.003. |
| Last Update |
| 2017-10-11 15:00:25 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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