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Class of 1999
Name
Preto, Ana
Nationality
Portuguese
E-Mail
apreto@bio.uminho.pt
1st Degree
Pharmaceutical Sciences
University (1st Degree)
University of Porto
About the PhD
Field of Research
Oncobiology
Thesis Title
IDENTIFICATION OF POTENTIAL MECHANISMS OF TOLERANCE TO WILD-TYPE P53 IN HUMAN CARCINOGENESIS USING THYROID NEOPLASIA AS A PROTOTYPE
Supervisor(s)
Professor Manuel Sobrinho-Simões
Co-Supervisor(s)
Doctor Christopher Jones
University
University of Porto and University of Wales College of Medicine
Laboratory
IPATIMUP
City
Porto
Country
Portugal
Date of Thesis Defence
2004-01-30
After the PhD (Current Situation)
Position
Assistant Professor at the Department of Biology, Researcher at CBMA
Project
Oncobiology and Nanomedicine
Institution
Department of Biology, CBMA, University of Minho
View Institution website
City
Braga
Country
Portugal

Relevant Publications
Marques C, Oliveira CSF, Alves S, Chaves SR, Coutinho OP, Côrte-Real M, Preto A. “Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release”. Cell Death and Disease (2013) Feb 21;4:e507. doi: 10.1038/cddis.2013.29.
João Azevedo-Silva, Odilia Queirós, Fatima Baltazar, Young H. KO, Peter Pedersen, Ana Preto, Margarida Casal. “The cytotoxicity of 3-Bromopyruvate in breast cancer cells depends on extracellular pH”. Biochem J. 2015 Apr 15;467(2):247-58.
doi: 10.1042/BJ20140921.
Oliveira CSF, Pereira H, Alves S, Castro L, Baltazar F, Chaves SR, Côrte-Real M, Preto A."Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria". Cell Death Dis. 2015 Jun 18;6:e1788. doi: 10.1038/cddis.2015.157.
Amorim R, Pinheiro C, Miranda-Gonçalves V, Pereira H, Moyer MP, Preto A, Baltazar F. “Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells.” Cancer Lett. 2015 Aug 28;365(1):68-78.
doi: 10.1016/j.canlet.2015.05.015.

Alves S, Castro L, Fernandes MS, Francisco R, Castro P, Priault M, Chaves SR, Moyer MP, Oliveira C, Seruca R, Côrte-Real M, Sousa MJ, Preto A. “Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy”. Oncotarget. 2015 Oct 13;6(31):30787-802. doi: 10.18632/oncotarget.5021.
Eugénia Nogueira, Franck Lager, Delphine Le Roux, Patrícia Nogueira, Jaime Freitas, Celine Charvet, Gilles Renault, Ana Loureiro, Catarina R. Almeida, Anna Ohradanova-Repic, Christian Machacek, Gonçalo J. L. Bernardes, Alexandra Moreira, Hannes Stockinger, Michael Burnet, Alexandre M. Carmo, Andreia C. Gomes, Ana Preto, Georges Bismuth and Artur Cavaco-Paulo. "Enhancing methotrexate tolerance with folate tagged liposomes in arthritic mice." Journal of Biomedical Nanotechnology, 2015, 11(12), 2243-2252.
Nogueira E., MangialavoriI. C., Loureiro A., Azoia N. G., Sárria M. P., Nogueira P., Freitas J., Harmark, J., Shimanovich U., Rollett A., Lacroix G., Bernardes G. J. L., Guebitz G., Hebert H., Moreira A., Carmo A. M., Rossi J. P. F. C., Gomes A. C., Preto A. and Cavaco-Paulo A. “Peptide anchor for folate-targeted liposomal delivery”. Biomacromolecules, 2015, 16(9), 2904-2910.
Eugénia Nogueira, Andreia Gomes, Ana Preto and Artur Cavaco-Paulo. “Design of Liposomal Formulations for Cell Targeting”. Colloids Surf B Biointerfaces. 2015 Dec 1;136:514-26. doi: 10.1016/j.colsurfb.2015.09.034.
Eugénia Nogueira, Andreia Gomes, Ana Preto and Artur Cavaco-Paulo. “Folate-targeted nanoparticles for rheumatoid arthritis therapy.” Nanomedicine. 2015 Dec 28. pii: S1549-9634(15)00610-3. doi: 10.1016/j.nano.2015.12.365.
Nogueira E, Cruz CF, Loureiro A, Nogueira P, Freitas J, Moreira A, Carmo AM, Gomes AC, Preto A, Cavaco-Paulo A.. “Assessment of nanocapsule disruption to drug delivery in vitro”. Biochim Biophys Acta. 2016 Feb;1858(2):163-7. doi: 10.1016/j.bbamem.2015.11.008.
Azevedo-Silva J., Ko Y. H., Pedersen P. L., Preto A., Casal M. “Anticancer agent 3BP: license to kill. “3-Bromopyruvate: from a simple molecule to the bedside of oncology patients”. J Bioenerg Biomembr. 2016 Aug;48(4):349-62. doi: 10.1007/s10863-016-9670-z
Ferro S, Azevedo-Silva J, Casal M, Côrte-Real M, Baltazar F, Preto A. “Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications”, Oncotarget. 2016 Sep 21. doi: 10.18632/oncotarget.12156.


Giulia Cazanelli, Suellen Ferro, Tiago Moreira, João Silva, Eugenia Nogueira, Ana Preto. Colorectal cancer therapeutic approaches: from classical drugs to new nanoparticles. Frontiers in Anti-Cancer Drug Discovery, 2016, Vol7, 3-82. Chapter3. Bentham eBooks, Bentham Science Publishers.

Publications
Queirós O, Preto A, Pacheco A, Pinheiro C, Silva J, Moreira R, Pedro M, Ko Y, Pederson P, Baltazar F and Casal M. “Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate”. J Bioenerg Biomembr 2012, 44(1):141-53. http://hdl.handle.net/1822/21366
Nogueira E, Loureiro A, Nogueira P, Freitas J, R. Almeida CR, Härmark J, Hebert H, Moreira A, Carmo AM, Preto A, Gomes AC, Cavaco-Paulo A. “Liposome and protein based stealth nanoparticles”. Faraday Discussions 2013, DOI: 10.1039/C3FD00057E
Baltazar F, Pinheiro C, Morais-Santos F, Azevedo-Silva J, Queirós O, Preto A, Casal M. “Monocarboxylate transporters as targets and mediators in cancer therapy response”. Histol Histopathol. 2014 Dec;29(12):1511-1524. Epub 2014 Jun 12.
Ana Loureiro, Gonçalo J. L. Bernardesc, Ulyana Shimanovichc, Marisa Passos Sárriaa,b, Eugénia Nogueira, Ana Preto, Andreia C. Gomesb, Artur Cavaco-Paulo. “Folic Acid-Tagged Protein Nanoemulsions Loaded with CORM-2 Enhance the Survival of Mice Bearing Subcutaneous A20 Lymphoma Tumors”, Nanomedicine. 2015 Jul;11(5):1077-83. doi: 10.1016/j.nano.2015.02.022.
Ana Loureiro, Eugénia Nogueira, Nuno G. Azoia, Marisa Passos Sárria, Ana Sofia Abreu, Ulyana Shimanovich, Alexandra Rollett, Johan Härmark, Hans Hebert, Georg Guebitz, Gonçalo J. L. Bernardes, Ana Preto, Andreia C. Gomes, Artur Cavaco-Paulo. “Size Controlled Protein Nanoemulsions for Active Targeting of Folate Receptor Positive Cells”. Colloids and Surfaces B: Biointerfaces, 2015, 135, 90-98. doi:10.1016/j.colsurfb.2015.06.073

[more publications]
Last Update
2017-10-11 15:00:25

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