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| Name |
| Lages Alves, Nuno |
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| E-Mail |
| nalves@ibmc.up.pt |
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| About the PhD |
| Field of Research |
| Immunology |
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| Thesis Title |
| Visualizing IL-7 expresion in vivo (Pasteur Institute - Paris) |
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| Abstract |
Research Interest
My interest is focused on the function of the Thymus, the primary lymphoid organ responsible for the generation of T cells.
Epithelial cells within the thymus provide essential signals to promote T... |
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Research Interest
My interest is focused on the function of the Thymus, the primary lymphoid organ responsible for the generation of T cells.
Epithelial cells within the thymus provide essential signals to promote T cell differentiation. Our studies aim at investigating the cellular and molecular pathways involved in Thymic Epithelial Cell development, differentiation and function. We use a variety of approaches to accomplish these goals, including in vivo analysis of mutant mice, in vitro thymic organotypic cultures, in vivo thymic transplantation assays and transcriptome analysis.
Projects as Principal Investigator
Fundação para a Ciência e Tecnologia, Portugal
PTDC/SAU- IMU/110116/2009. Unveiling the thymic interleukin 7 niche in vivo - A framework to study the cellular and molecular control of a master regulator of T lymphopoiesis.
PTDC/SAU- IMU/117057/2010. The function of the thymus in pathophysiological conditions: A systematic approach to study the expression of interleukin 7 during stress-induced thymic injury.
Universidade do Porto
Projecto Pluridisciplinar 2010. Unveiling the thymic interleukin 7 niche in vivo.
Supervision
PhD students: Ana Ribeiro (FCT-SFRH/BD/78380/2011) and Pedro Rodrigues (FCT-SFRH/BD/86605/2012).
Research fellow: Catarina Meireles
References
Alves NL, Huntington ND, Mention JJ, Richard-Le Goff O, Di Santo JP. Cutting Edge: A thymocyte-thymic epithelial cell crosstalk dynamically regulates intrathymic IL-7 expression in vivo. J Immunol. 2010 Jun 1;184(11):5949-5953
Alves NL, Richard-Le Goff O, Huntington ND, Sousa AP, Ribeiro VS, Bordack A, Vives FL, Peduto L, Chidgey A, Cumano A, Boyd R, Eberl G, Di Santo JP. Characterization of the thymic IL-7 niche in vivo. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1512-1517. |
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| Supervisor(s) |
| Prof. Dr. Rene van Lier |
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| Co-Supervisor(s) |
| Prof. Dr. Fernando Arosa; Prof. Dr. Eric Eldering |
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| University |
| Amsterdam |
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| Laboratory |
| Academical Medical Center - Dep Immunology |
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| Date of Thesis Defence |
| 2007-01-24 |
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| After the PhD (Current Situation) |
| Position |
| Associate Research Scientist |
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| Project |
| Ciência 2008 |
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| Institution |
| IBMC |
| View Institution website |
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| Relevant Publications |
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Alves NL, Ester M.M. van Leeuwen, Ingrid A.M. Derks and René A.W. van Lier. Differential regulation of human IL-7 receptor alpha expression by IL-7 and TCR signaling .
J Immunol. 2008 Apr 15;180(8):5201-10
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Alves NL, van Leeuwen EM, Remmerswaal EB, Vrisekoop N, Tesselaar K, Roosnek E, Ten Berge IJ, van Lier RA.
A New Subset of Human Naive CD8+ T Cells Defined by Low Expression of IL-7R{alpha}.
J Immunol. 2007 Jul 1;179(1):221-8.
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| Alves NL, Derks IA, Berk E, Spijker R, van Lier RA, Eldering E. “The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells”. Immunity 2006 Jun;24(6):703-16. |
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Alves NL, Arosa FA and van Lier RA. }3IL-21 Sustains CD28 Expression on IL-15-Activated Human Naive CD8+ T Cells}4.
J Immunol. 2005 Jul 15;175(2):755-62.
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| Alves NL, Hooibrink B, Arosa FA, van Lier RA. Blood. 2003 Oct 1;102(7):2541-6. Epub 2003 Jun 12. }3IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.}4 |
| Last Update |
| 2013-03-14 15:06:28 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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