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Class of 2000
Name
Santos, Susana G.
E-Mail
susana.santos@ineb.up.pt
Master Degree
Biomedical Sciences
About the PhD
Field of Research
Immunology
Thesis Title
Inflammatory Response to Biomaterials
Supervisor(s)
Dr. Fernando A. Arosa, and Dr. Simon J. Powis
University
ICBAS - University of Porto
Laboratory
IBMC, ICBAS - University of Porto, and CLS - University of Dundee
Date of Thesis Defence
2005-10-07

Relevant Publications
Misfolding of major histocompatibility complex class I molecules in activated T cells allows cis-interactions with receptors and signaling molecules and is associated with tyrosine phosphorylation. (2004)
Santos SG, Powis SJ, Arosa FA.
J Biol Chem, 279:53062-70
View Publication
Lack of tyrosine 320 impairs spontaneous endocytosis and enhances release of HLA-B27 molecules. (2006)
Santos SG, Antoniou AN, Sampaio P, Powis SJ, Arosa FA.
J Immunol, 176:2942-9.
View Publication
Major histocompatibility complex class I-ERp57-tapasin interactions within the peptide-loading complex. (2007)
Santos SG, Campbell EC, Lynch S, Wong V, Antoniou AN, Powis SJ
J Biol Chem, 282:17587-93
View Publication
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. (2008)
Ananieva O, Darragh J, Johansen C, Carr JM, McIlrath J, Park JM, Wingate A, Monk CE, Toth R, Santos SG, Iversen L, Arthur JS.
Nat Immunol, 9:1028-36
View Publication
Induction of HLA-B27 heavy chain homodimer formation after activation in dendritic cells. (2008)
Santos SG, Lynch S, Campbell EC, Antoniou AN, Powis SJ.
Arthritis Res Ther, 10:R100. [Epub ahead of print]
View Publication

Publications
Open conformers: the hidden face of MHC-I molecules.
Arosa FA, Santos SG, Powis SJ.
Trends Immunol, 28:115-23
View Publication
ERp57 interacts with conserved cysteine residues in the MHC class I peptide-binding groove.
Antoniou AN, Santos SG, Campbell EC, Lynch S, Arosa FA, Powis SJ.
FEBS Lett, 581:1988-92
View Publication
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology