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| Name |
| Taborda Barata, João |
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| Nationality |
| Portuguese |
| E-Mail |
| joao_barata@fm.ul.pt |
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| Master Degree |
| Biology |
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| University (Master Degree) |
| University of Coimbra, Portugal |
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| About the PhD |
| Field of Research |
| Oncobiology, Signal Transduction |
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| Thesis Title |
| Microenvironmental and cell-autonomous mechanisms involved in tumor progression |
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| Supervisor(s) |
| Angelo Cardoso, Vassiliki Boussiotis |
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| Co-Supervisor(s) |
| Maria de Sousa |
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| University |
| University of Porto |
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| Laboratory |
| Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Instituto de Medicina Molecular, Lisbon University Medical School, Lisboa, Portugal |
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| Date of Thesis Defence |
| 2003-03-28 |
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| After the PhD (Current Situation) |
| Position |
| Research Group Leader |
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| Project |
| Cancer Biology Unit |
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| Institution |
| Instituto de Medicina Molecular |
| View Institution website |
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| City |
| Lisboa |
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| Country |
| Portugal |
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| Relevant Publications |
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| C.M. Henriques, J. Rino, R.J. Nibbs, G.G. Graham, J.T. Barata (2010). IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Rα in T cells. Blood 115 (16): 3269-3277. |
| View Publication |
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| L.R. Martins, P. Lúcio, M.C. Silva, P. Gameiro, M.G. Silva, J.T. Barata (2010). Targeting CK2 Overexpression and Hyperactivation as a Novel Therapeutic Tool in Chronic Lymphocytic Leukemia. Blood 116 (15): 2724-2731. |
| View Publication |
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| A. Silva, A.B.A. Laranjeira, L.R. Martins, B.A. Cardoso, J. Demengeot, J.A. Yunes, B. Seddon, J.T. Barata (2011). IL-7 contributes to the progression of human T-cell acute lymphoblastic leukemias. Cancer Research 71 (14): 4780-4789. |
| View Publication |
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| P.P. Zenatti, D. Ribeiro, W. Li, L. Zuurbier, M.C. Silva, M. Paganin, J. Tritapoe, J.A. Hixon, A.B. Silveira, B.A. Cardoso, L.M. Sarmento, N. Correia, M.L. Toribio, J. Kobarg, M. Horstmann, R. Pieters, S.R. Brandalise, A.A. Ferrando, J.P. Meijerink, S.K. Durum, J.A. Yunes, J.T. Barata (2011). Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nature Genetics 43 (10): 932-939. |
| View Publication |
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| N. Correia, K. Durinck, A.P. Leite, M. Ongenaert, P. Rondou, F. Speleman, F.J. Enguita, J.T. Barata (2013). Novel TAL1 targets beyond protein-coding genes: identification of TAL1-regulated microRNAs in T-cell acute lymphoblastic leukemia. Leukemia 27 (7): 1603-1606. |
| View Publication |
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| J.T. Barata, A. Silva, J.G. Brandão, L.M. Nadler, A.A. Cardoso, V.A. Boussiotis (2004). Activation of PI3K is Indispensable for Interleukin 7-Mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells. Journal of Experimental Medicine 200 (5): 659-669. |
| View Publication |
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| A. Silva, J.A. Yunes, B.A. Cardoso, L.R. Martins, P.Y. Jotta, M. Abecasis, A.E. Nowill, N.R. Leslie, A.A. Cardoso, J.T. Barata (2008). PTEN Posttranslational Inactivation and Hyperactivation of the PI3K/Akt Pathway Sustain Primary T Cell Leukemia Viability. Journal of Clinical Investigation 118 (11): 3762-3774. |
| View Publication |
| Publications |
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| R.I. Azevedo, M.V.D. Soares, J.T. Barata, R. Tendeiro, A. Serra-Caetano, R.M.M. Victorino and A.E. Sousa (2009). IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner. Blood 113 (13): 2999-3007. |
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| D.V. Correia, F. d’Orey, B.A. Cardoso, T. Lança, A.R. Grosso, A. deBarros, L.R. Martins, J.T. Barata, B. Silva-Santos (2009). Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human γδ T-cells. PLoS ONE 4 (5): e5657. |
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| P.Y. Jotta, M.A. Ganazza, A. Silva, M.B. Viana, M.J. da Silva, L.J.G. Zambaldi, J.T. Barata, S.R. Brandalise, J.A. Yunes (2010). Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. Leukemia 24 (1): 239-42. |
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| A. Silva, P.Y. Jotta, A.B. Silveira, D. Ribeiro, S.R. Brandalise, J.A. Yunes, J.T. Barata (2010). Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and gamma-secretase inhibitors. Haematologica 95 (4): 674-678. |
| View Publication |
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| I.S. Vala, L.R. Martins, N. Imaizumi, R.J. Nunes, J. Rino, F. Kuonen, L.M. Carvalho, C. Ruegg, I. Monteiro Grillo, J.T. Barata, M. Mareel, S.C.R. Santos (2010). Low Doses of Ionizing Radiation Promote Tumor Growth and Metastasis by Enhancing Angiogenesis. PLoS ONE 5(6): e11222. |
[more publications]
| More Publications |
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| C. Grimaldi, F. Chiarini, G. Tabellini, F. Ricci, P.L. Tazzari, M. Battistelli, E. Falcieri, R. Bortul, F. Melchionda, I. Iacobucci, P. Pagliaro, G. Martinelli, A. Pession, J.T. Barata, J.A. McCubrey and A.M. Martelli (2012). AMP-Dependent Kinase/Mammalian Target of Rapamycin Complex 1 Signaling in T-Cell Acute Lymphoblastic Leukemia: Therapeutic Implications. Leukemia 26 (1): 91-100. |
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| J.T. Barata (2013). IL-7Rα: Mr Hyde's twists and turns. Blood 122 (26): 4151-4152. |
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| L.R. Martins, P. Lúcio, A. Melão, I. Antunes, B.A. Cardoso, R. Stansfield, M.T. Bertilaccio, P. Ghia, D. Drygin, M.G. Silva, J.T. Barata (2014). Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia. Leukemia 28 (1): 179–182. |
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| J.T. Barata, A.A. Cardoso, L.M. Nadler, V.A. Boussiotis (2001). Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27kip1. Blood 98 (5): 1524-1531. |
| View Publication |
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| J.T. Barata, V.A. Boussiotis, J.A. Yunes, A.A. Ferrando, L.A. Moreau, J.P. Veiga, S.E. Sallan, A.T. Look, L.M. Nadler, A.A. Cardoso (2004). IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. Blood 103 (5): 1891-1900. |
| View Publication |
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| J.T. Barata, T.D. Keenan, A. Silva, L.M. Nadler, V.A. Boussiotis, A.A. Cardoso (2004). Common Gamma Chain-Signaling Cytokines Promote Proliferation of T-Cell Acute Lymphoblastic Leukemia. Haematologica 89 (12): 1459-1467. |
| View Publication |
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| J.T. Barata*, A.A. Cardoso, V.A. Boussiotis (2005). Interleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis? Leukemia and lymphoma 46 (4): 483-495. *corresponding author |
| View Publication |
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| J.T. Barata*, A. Silva, M. Abecasis, N. Carlesso, A. Cumano, A.A. Cardoso (2006). Molecular and Functional Evidence for Activity of Murine IL-7 on Human Lymphocytes. Experimental Hematology 34 (9): 1132-1141. *corresponding author |
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| S.C. Santos, I. Vala, C. Miguel, J.T. Barata, P. Garcao, P. Agostinho, M. Mendes, A.V. Coelho, A. Calado, C.R. Oliveira, J. Martins E Silva, C. Saldanha (2007). Expression and subcellular localization of a novel nuclear acetylcholinesterase protein. Journal of Biological Chemistry 282(35):25597-25603. |
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| B.A. Cardoso, A. Gírio, C. Henriques, L.R. Martins, C. Santos, A. Silva, J.T. Barata (2008). Common Aberrant signaling in T-cell acute lymphoblastic leukemia: biological and therapeutic implications. Brazilian Journal of Medical and Biological Research 41 (5): 344-350. |
| View Publication |
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| B.A. Cardoso, L.R. Martins, C.I. Santos, L.M. Nadler, V.A. Boussiotis, A.A. Cardoso, J.T. Barata (2009). Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling. Leukemia 23 (1): 206-208. |
| Last Update |
| 2014-04-29 16:18:52 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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