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Class of 2002
Cruz, Andrea
1st Degree
University (1st Degree)
Escola Superior de Biotecnologia _ Universidade Católica Portuguesa
Master Degree
University (Master Degree)
The Montfort University
About the PhD
Field of Research
Thesis Title
Understanding BCG vaccination: implications for the design of new preventive strategies against mycobacteriosis
António Gil Castro
Jorge Pedrosa and Andrea Cooper
Universidade Minho
Microbiology and Infection domain
Date of Thesis Defence

Relevant Publications
Andrea Cruz, Alexandra G. Fraga, Jeffrey Fountain, Javier Rangel-Moreno, Egídio Torrado, Margarida Saraiva, Daniela Pereira, Jorge Pedrosa, Andrea M. Cooper and António G. Castro. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med. 2010; 207:1609-16

Alexandra G. Fraga, Andrea Cruz, Teresa G. Martins, Egidio Torrado, Margarida Saraiva, Daniela R. Pereira, Wayne Meyers, Françoise Portaels F, Manuel T. Silva, António G. Castro. Jorge Pedrosa. Mycobacterium ulcerans triggers T-cell immunity followed by local and regional but not systemic immunosuppression. Infect Immun. 2011 Jan;79(1):421-30
Maria Teixeira-Coelho, Andrea Cruz, Jenny Carmona , Carole Sousa , Daniela R. Pereira, Ana Saraiva, Mark Veldhoen, Jorge Pedrosa, António Castro, Margarida Saraiva. TLR2 deficiency by compromising p19 (IL-23) expression limits Th17 cell responses to Mycobacterium tuberculosis. Int Immunol. 2011 Feb;23(2):89-96.
M. M. Gaspar, A. Cruz, A.F. Penha, J. Reymão, A. C. Sousa, C. V. Eleutério, S. A. Domingues, A. G. Fraga, A. Longatto Filho, M. E. M.Cruz, J. Pedrosa. Rifabutin encapsulated in liposomes exhibits increased therapeutic activity in a model of disseminated tuberculosis. International Journal of Antimicrobial Agents, 1:37-45
Andrea Cruz, Shabaana A. Khader, Egidio Torrado, Alexandra Fraga, John E. Pearl, Jorge Pedrosa, Andrea M. Cooper, António G. Castro. IFN- regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. Cutting Edge. Journal of Immunology, 177:1416-1420.
Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA., Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen. Cancer Res. 2004 Oct 1;64(19):7050-7.

Manuel Lima-Rodrigues, Nuno Lamas, Ana Valle-Fernandes, Andrea Cruz, Artur Vieira, Pedro Oliveira, Jorge Pedrosa, António G. Castro, Rui M. Reis, Fátima Baltazar, Armando Almeida. The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment. Inflamm Res. 2010 Sep;59(9):743-53.
Gaspar MM, Cruz A, Fraga AG, Castro AG, Cruz MEM, Pedrosa J. Developments on drug delivery systems for the treatment of mycobacterial infections. Curr. Topics Med. Chem. 2008, 8(7):579-91, Review
Manuel Lima-Rodrigues, Ana Valle-Fernandes, Nuno Lamas, Andrea Cruz, Fátima Baltazar, Fernanda Milanezi, Rui Nunes, Rui M Reis, António G Castro, Armando Almeida. A New Model of Laryngitis: neuropeptide, COX and cytokine profile. The Laryngoscope, 118 (1) 78-86
Marcos N., Cruz A., Silva F., Almeida R., David L., Mandel U., Clausen H., Mensdorff-Pouilly S., Reis C., (2003) Polypeptide GalNAc-transferase, ST6GalNAc-transferase I, and ST3Gal-transferase I Expression in Gastric Carcinoma Cell Lines. The Journal of Histochemistry & Cytochemistry, Jun: 51(6) : 761-71
Last Update
2013-04-10 09:54:22
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