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Class of 2002
Cruz, Andrea
1st Degree
University (1st Degree)
Escola Superior de Biotecnologia _ Universidade Católica Portuguesa
Master Degree
University (Master Degree)
The Montfort University
About the PhD
Field of Research
Thesis Title
Understanding BCG vaccination: implications for the design of new preventive strategies against mycobacteriosis
António Gil Castro
Jorge Pedrosa and Andrea Cooper
Universidade Minho
Microbiology and Infection domain
Date of Thesis Defence
After the PhD (Current Situation)
Marie Curie Fellow
Identification of actomyosin-based biomarkers relevant for microglia activation.
International Iberian Nanotechnology Laboratory

Relevant Publications
Andrea Cruz, Alexandra G. Fraga, Jeffrey Fountain, Javier Rangel-Moreno, Egídio Torrado, Margarida Saraiva, Daniela Pereira, Jorge Pedrosa, Andrea M. Cooper and António G. Castro. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med. 2010; 207:1609-16

Alexandra G. Fraga, Andrea Cruz, Teresa G. Martins, Egidio Torrado, Margarida Saraiva, Daniela R. Pereira, Wayne Meyers, Françoise Portaels F, Manuel T. Silva, António G. Castro. Jorge Pedrosa. Mycobacterium ulcerans triggers T-cell immunity followed by local and regional but not systemic immunosuppression. Infect Immun. 2011 Jan;79(1):421-30
Andrea Cruz, Egídio Torrado, Jenny Carmona, Alexandra G. Fraga, Patrício Costa, Fernando Rodrigues, Rui Appelberg, Margarida Correia-Neves, Andrea M. Cooper, Margarida Saraiva, Jorge Pedrosa, António G. Castro. BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells. Vaccine 2015, 33, 85–91.
Andrea Cruz, Paula Ludovico, Egidio Torrado, José Bernardo Gama, Jeremy Sousa, Joana Gaifem, Rui Appelberg, Fernando Rodrigues, Andrea M Cooper, Jorge Pedrosa, Margarida Saraiva. IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages. Front. Immunol. 6:498. doi: 10.3389/fimmu.2015.00498
Helena S. Domingues, Andrea Cruz, Jonah R. Chan, João B. Relvas, Boris Rubinstein, Inês Mendes Pinto. Mechanical plasticity during oligodendrocyte differentiation and myelination, Glia. 1–10
Flávia Sousa, Andrea Cruz, Pedro Fonte, Inês Mendes Pinto, Maria Teresa Neves-Petersen, Bruno Sarmento. A new paradigm for antiangiogenic therapy through controlled release of bevacizumab from PLGA nanoparticles. Scientific Reports Jun 16;7(1):3736
Sandra O. Braz*, Andrea Cruz*, Andrea Lobo*, Joana Bravo, Joana Moreira-Ribeiro, Isabel Pereira-Castro, Jaime Freitas, Joao B. Relvas, Teresa Summavielle, Alexandra Moreira. Expression of Rac1 alternative 3`UTRs is a cell specific mechanism with a function in dendrite outgrowth in cortical neurons. BBA Gene Regulatory Mechanisms (2017), doi:10.1016/j.bbagrm.2017.03.002. * These authors contribute equally to the work
Andrea Cruz, Shabaana A. Khader, Egidio Torrado, Alexandra Fraga, John E. Pearl, Jorge Pedrosa, Andrea M. Cooper, António G. Castro. IFN- regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infection. Cutting Edge. Journal of Immunology, 177:1416-1420.

Manuel Lima-Rodrigues, Nuno Lamas, Ana Valle-Fernandes, Andrea Cruz, Artur Vieira, Pedro Oliveira, Jorge Pedrosa, António G. Castro, Rui M. Reis, Fátima Baltazar, Armando Almeida. The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment. Inflamm Res. 2010 Sep;59(9):743-53.
Maria Teixeira-Coelho, Andrea Cruz, Jenny Carmona , Carole Sousa , Daniela R. Pereira, Ana Saraiva, Mark Veldhoen, Jorge Pedrosa, António Castro, Margarida Saraiva. TLR2 deficiency by compromising p19 (IL-23) expression limits Th17 cell responses to Mycobacterium tuberculosis. Int Immunol. 2011 Feb;23(2):89-96.
Jenny Carmona, Andrea Cruz, Lúcia Moreira-Teixeira, Carole Sousa, Jeremy Sousa, Nuno S. Osório, Ana L. Saraiva, Stefan Svenson, Gunilla Kallenius, Jorge Pedrosa, Fernando Rodrigues, António G. Castro and Margarida Saraiva. Mycobacterium tuberculosis strains are differentially recognized by TLRs with an impact on the immune response. PLoS ONE 2013 8(6): e67277.
Ana Curinha, Sandra Oliveira Braz, Isabel Pereira-Castro, Andrea Cruz, Alexandra Moreira. Implications of polyadenylation in health and disease. Nucleus 2014 Sep 5;5(6)
Diogo Teixeira*, Andrea Cruz*, Sandra Braz, Alexandra Moreira, João Relvas, Rui Camacho. “PBS Finder: A Tool to Assist RNA Binding Proteins Studies”, ACM's Digital Library, Symposium on Applied Computing (SAC 2015), 2015 Vol 1, pp 32-39 *shared authorship

[more publications]
Last Update
2017-10-11 09:50:01

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