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| Name |
| Passos, Joăo |
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| E-Mail |
| joao.passos@newcastle.ac.uk |
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| 1st Degree |
| Biochemistry |
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| About the PhD |
| Field of Research |
| Biogerontology |
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| Thesis Title |
| Role of mitochondria in Telomere-dependent Senescence |
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| Supervisor(s) |
| Professor Tom Kirkwood |
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| Co-Supervisor(s) |
| Professor Thomas von Zglinicki |
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| University |
| Universidade do Porto |
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| Laboratory |
| Henry Wellcome lab for Biogerontology Research |
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| Date of Thesis Defence |
| 2007-01-02 |
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| Relevant Publications |
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Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TB, von Zglinicki T.
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.
PLoS Biol. 2007 May;5(5):e110. |
| View Publication |
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| Passos JF, von Zglinicki T, Kirkwood TB. Mitochondria and ageing: winning and losing in the numbers game Bioessays. 2007 Sep;29(9):908-17 |
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| Passos JF, Saretzki G, von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res. 2007;35(22):7505-13. |
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| Passos JF Portugal gets ready to embrace ageing research Jun;9(3):209-11. Biogerontology 2008 |
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Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G.
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci. 2008 |
| Publications |
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| Soleimanpour-Lichaei HR, Kühl I, Gaisne M, Passos JF, Wydro M, Rorbach J, Temperley R, Bonnefoy N, Tate W, Lightowlers R, Chrzanowska-Lightowlers Z.The newly identified protein mtRF1a, is a human mitochondrial translation release factor, decoding the major termination codons UAA and UAG Molecular Cell 2007 27(5):745-57. |
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| Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN, Stewart R, Hoare S, Stojkovic M, Armstrong L, von Zglinicki T, Lako M Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.Stem Cells. 2008 Feb;26(2):455-64 |
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| Passos JF, Von Zglinicki T Oxygen free radicals in cell senescence: are they signal transducers? Free Radic Res. 2006 Dec;40(12):1277-83 |
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| Passos JF, von Zglinicki T, Saretzki G Mitochondrial dysfunction and cell senescence: cause or consequence? Rejuvenation Res. 2006 Spring;9(1):64-8 |
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| Passos JF and von Zglinicki T Mitochondria, telomeres and cell senescence Mini Review Exp Gerontology 40, 466-472 (2005) |
[more publications]
| More Publications |
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| Pacheco CC, Passos JF, Castro AR, Moradas-Ferreira P and De Marco P Role of respiration and glutathione in Cd-induced oxidative stress in Escherichia coli K-12 Arch Microbiol. 2008 Mar;189(3):271-8 |
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| Getliffe KM, Martin-Ruiz C, Passos JF, von Zglinicki T and Nwokolo CU Extended lifespan and long telomeres in rectal fibroblasts from late-onset ulcerative colitis patients. European Journal of Gastroenterology & Hepatology. 18(2):133-141, February 2006 |
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| Pacheco CC, Passos JF, Moradas-Ferreira P, De Marco P 2003 Strain PM2, a novel methylotrophic fluorescent Pseudomonas sp. FEMS Microbiol Lett. 2003 Oct 24;227(2):279-85 |
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| Ksiazek K, Passos JF, Olijslagers S, Saretzki G, Martin-Ruiz C and von Zglinicki T. Premature senescence of mesothelial cells is associated with non-telomeric DNA damage. Biochem Biophys Res Commun. 2007 Oct 26;362(3):707-11 |
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| Ksiazek K, Passos JF, Olijslagers S and T von Zglinicki. Mitochondrial dysfunction is a possible cause of accelerated senescence of mesothelial cells exposed to high glucose. Biochem Biophys Res Commun.2008 Feb 15;366(3):793-9 |
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| Passos JF, von Zglinicki T.Methods for cell sorting of young and senescent cells.Methods Mol Biol. 2007;371:33-44 |
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| Passos JF and von Zglinicki T, Retrograde response, oxidative stress and cellular senescence book chapter on Oxidative stress in aging editors: F. Muller, S. Miwa, K. Beckman, Humana Press (2008) |
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| Passos JF, Nelson G and von Zglinicki T, Telomeres, Senescence, Oxidative stress and heterogeneity book chapter on Telomeres and telomerase in ageing, disease, and cancer editor: KL Rudolph, Springer (2007) |
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| Passos JF and Kirkwood TB Biological and physiological aspects of aging Textbook of Geriatric Dentistry editors: Poul Holm-Pedersen, Angus Walls and Jonathan Ship Blackwell publishing |
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| Tsolou A, Passos JF, Nelson G, Arai Y and von Zglinicki T. ssDNA fragments induce cell senescence by telomere uncapping. Exp Gerontol. 2008 Aug 22. |
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| Birket MJ, Passos JF, von Zglinicki T and Birch-Machin M The relationship between the ageing- and photo-dependent T414G mitochondrial DNA mutation with cellular senescence and reactive oxygen species production in cultured skin fibroblasts JID in Press |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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