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Class of 2002
Name
Passos, Joăo
E-Mail
joao.passos@newcastle.ac.uk
1st Degree
Biochemistry
About the PhD
Field of Research
Biogerontology
Thesis Title
Role of mitochondria in Telomere-dependent Senescence
Supervisor(s)
Professor Tom Kirkwood
Co-Supervisor(s)
Professor Thomas von Zglinicki
University
Universidade do Porto
Laboratory
Henry Wellcome lab for Biogerontology Research
Date of Thesis Defence
2007-01-02

Relevant Publications
Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TB, von Zglinicki T.
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.
PLoS Biol. 2007 May;5(5):e110.
View Publication
Passos JF, von Zglinicki T, Kirkwood TB. Mitochondria and ageing: winning and losing in the numbers game Bioessays. 2007 Sep;29(9):908-17
Passos JF, Saretzki G, von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res. 2007;35(22):7505-13.
Passos JF Portugal gets ready to embrace ageing research Jun;9(3):209-11. Biogerontology 2008
Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G.
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci. 2008

Publications
Soleimanpour-Lichaei HR, Kühl I, Gaisne M, Passos JF, Wydro M, Rorbach J, Temperley R, Bonnefoy N, Tate W, Lightowlers R, Chrzanowska-Lightowlers Z.The newly identified protein mtRF1a, is a human mitochondrial translation release factor, decoding the major termination codons UAA and UAG Molecular Cell 2007 27(5):745-57.
Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN, Stewart R, Hoare S, Stojkovic M, Armstrong L, von Zglinicki T, Lako M Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.Stem Cells. 2008 Feb;26(2):455-64
Passos JF, Von Zglinicki T Oxygen free radicals in cell senescence: are they signal transducers? Free Radic Res. 2006 Dec;40(12):1277-83
Passos JF, von Zglinicki T, Saretzki G Mitochondrial dysfunction and cell senescence: cause or consequence? Rejuvenation Res. 2006 Spring;9(1):64-8
Passos JF and von Zglinicki T Mitochondria, telomeres and cell senescence Mini Review Exp Gerontology 40, 466-472 (2005)

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INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology