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Class of 2002
Passos, Joăo
1st Degree
About the PhD
Field of Research
Thesis Title
Role of mitochondria in Telomere-dependent Senescence
Professor Tom Kirkwood
Professor Thomas von Zglinicki
Universidade do Porto
Henry Wellcome lab for Biogerontology Research
Date of Thesis Defence

Relevant Publications
Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, Wappler I, Birket MJ, Harold G, Schaeuble K, Birch-Machin MA, Kirkwood TB, von Zglinicki T.
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence.
PLoS Biol. 2007 May;5(5):e110.
View Publication
Passos JF, von Zglinicki T, Kirkwood TB. Mitochondria and ageing: winning and losing in the numbers game Bioessays. 2007 Sep;29(9):908-17
Passos JF, Saretzki G, von Zglinicki T. DNA damage in telomeres and mitochondria during cellular senescence: is there a connection? Nucleic Acids Res. 2007;35(22):7505-13.
Passos JF Portugal gets ready to embrace ageing research Jun;9(3):209-11. Biogerontology 2008
Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-Machin MA, von Zglinicki T, Saretzki G.
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci. 2008

Soleimanpour-Lichaei HR, Kühl I, Gaisne M, Passos JF, Wydro M, Rorbach J, Temperley R, Bonnefoy N, Tate W, Lightowlers R, Chrzanowska-Lightowlers Z.The newly identified protein mtRF1a, is a human mitochondrial translation release factor, decoding the major termination codons UAA and UAG Molecular Cell 2007 27(5):745-57.
Saretzki G, Walter T, Atkinson S, Passos JF, Bareth B, Keith WN, Stewart R, Hoare S, Stojkovic M, Armstrong L, von Zglinicki T, Lako M Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells.Stem Cells. 2008 Feb;26(2):455-64
Passos JF, Von Zglinicki T Oxygen free radicals in cell senescence: are they signal transducers? Free Radic Res. 2006 Dec;40(12):1277-83
Passos JF, von Zglinicki T, Saretzki G Mitochondrial dysfunction and cell senescence: cause or consequence? Rejuvenation Res. 2006 Spring;9(1):64-8
Passos JF and von Zglinicki T Mitochondria, telomeres and cell senescence Mini Review Exp Gerontology 40, 466-472 (2005)

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