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Class of 2003
Name
Pereira, Carlos Filipe
Nationality
Portuguse
E-Mail
filipe.pereira@mssm.edu
1st Degree
Biology
University (1st Degree)
Faculty of Sciences University of Porto
About the PhD
Field of Research
Stem Cells & Epigenetics
Thesis Title
Epigenetic events underlying somatic cell reprogramming
Abstract
Although differentiated cells normally retain cell-type-specific gene expression patterns throughout their lifetime, cell identity can sometimes be modified or reversed in vivo by transdifferentiation, or experimentally through...
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Supervisor(s)
Amanda G. Fisher
University
Imperial College of London
Laboratory
Lymphocyte development group, MRC Clinical sciences centre
City
London
Country
UK
Date of Thesis Defence
2008-12-15
After the PhD (Current Situation)
Position
Postdoctoral researcher
Project
Programming hematopoietic stem cells for cell replacement therapy
Institution
Mount Sinai School of medicine
View Institution website
City
New York
Country
USA

Relevant Publications
Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG.ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency.
Cell Stem Cell. 2010 Jun 4;6(6):547-56.

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Pereira, C.F. *, Chang, B., Qiu, J., Niu, X., Papatsenko, D., Hendry, C.E., Clark, N.R., Nomura-Kitabayashi A., Kovacic J.C., Ma’ayan A., Schaniel C., Lemischka, I.R., Moore, K.A* (2013). Induction of a Hemogenic Program in Mouse Fibroblasts. Cell Stem Cell. 13, 205-18. *corresponding authors.
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Terranova, R., Pereira, C. F., Du Roure, C., Merkenschlager, M., and Fisher, A. G. (2006). Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming. J Cell Sci 119, 2065-2072.
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Pereira, C.F., Terranova, R., Ryan, N.K., Santos, J., Morris, K.M., Cui, W., Merkenschlager, M., Fisher, A.G. (2008). Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genet 4, e1000170.
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Pereira, C.F., Fisher, A.G. (2009) Heterokaryon-based reprogramming for pluripotency. Curr. Protoc. Stem Cell Biol. Chapter 4:Unit 4B.1.
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Banito A, Rashid ST, Acosta JC, Li S, Pereira CF, Geti I, Pinho S, Silva JC, Azuara V, Walsh M, Vallier L, Gil J. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 2009 Sep 15;23(18):2134-9. Epub 2009 Aug 20.
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Savarese F, Dávila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, Grosschedl R. Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev. 2009 Nov 15;23(22):2625-38.
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Publications
Jorgensen, H.F., Terry, A., Beretta, C., Pereira, C.F., Leleu, M., Chen,Z.F., Kelly, C., Merkenschlager, M., Fisher, A.G. (2009). REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development. 136, 715-721.
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Correia, M.P., Cardoso, E.M., Pereira, C.F., Neves, R., Uhrberg, M., Arosa, F.A. (2009). Hepatocytes and IL-15: a favorable microenvironment for T cell survival and CD8+ T cell differentiation. J Immunol. 182, 6149-59.
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Last Update
2014-04-10 19:16:36
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology