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Class of 2003
Name
Mancio-Silva, Liliana
Nationality
Portuguese
1st Degree
PharmD
About the PhD
Field of Research
Parasitology
Thesis Title
Gene regulation and nuclear architecture in malaria parasites
Supervisor(s)
Artur Scherf
University
University of Porto
Laboratory
Institut Pasteur, Biology of Host-Parasite Interactions Unit
City
Paris
Country
France
Date of Thesis Defence
2009-01-30
After the PhD (Current Situation)
Position
Post-doctoral fellow
Institution
Instituto de Medicina Molecular
View Institution website
City
Lisboa
Country
Portugal

Relevant Publications
Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A.
Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites.
Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15117-22.
View Publication
Mancio-Silva L, Lopez-Rubio JJ, Claes A, Scherf A.
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.
Nat Commun. 2013;4:1530. doi: 10.1038/ncomms2539.
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Freitas-Junior LH, Hernandez-Rivas R, Ralph SA, Montiel-Condado D, Ruvalcaba-Salazar OK, Rojas-Meza AP, Mancio-Silva L, Leal-Silvestre RJ, Gontijo AM, Shorte S, Scherf A.
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.
Cell. 2005 Apr 8;121(1):25-36.
View Publication
Mancio-Silva L, Rojas-Meza AP, Vargas M, Scherf A, Hernandez-Rivas R.
Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum.
J Cell Sci. 2008 Jun 15;121(Pt 12):2046-53.
View Publication
Lopez-Rubio JJ*, Mancio-Silva L*, Scherf A.
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites.
Cell Host Microbe. 2009 Feb 19;5(2):179-90. *co-first authors
View Publication

Publications
Issar N, Ralph SA, Mancio-Silva L, Keeling C, Scherf A.
Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.
Microbes Infect. 2009 Mar;11(3):403-7. Epub 2008 Dec 27.
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Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Mancio-Silva L, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF.
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
PLoS Biol. 2009 Apr 14;7(4):e84.
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Pena AC, Penacho N, Mancio-Silva L, Neres R, Seixas JD, Fernandes AC, Romăo CC, Mota MM, Bernardes GJ, Pamplona A.
A novel Carbon Monoxide-Releasing Molecule (CO-RM) fully protects mice from Severe Malaria.
Antimicrob Agents Chemother. 2011 Dec 12.
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Ribot JC, Debarros A, Mancio-Silva L, Pamplona A, Silva-Santos B.
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
J Immunol. 2012 Aug 1;189(3):1202-8. doi: 10.4049/jimmunol.1200268. Epub 2012 Jun 25.
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Sierra-Miranda M, Delgadillo DM, Mancio-Silva L, Vargas M, Villegas-Sepulveda N, Martínez-Calvillo S, Scherf A, Hernandez-Rivas R.
Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum.
Mol Biochem Parasitol. 2012 Sep;185(1):36-47. doi: 10.1016/j.molbiopara.2012.06.005. Epub 2012 Jun 18.
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[more publications]
Last Update
2012-03-24 11:11:56

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