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| Name |
| Mancio-Silva, Liliana |
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| Nationality |
| Portuguese |
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| 1st Degree |
| PharmD |
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| About the PhD |
| Field of Research |
| Parasitology |
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| Thesis Title |
| Gene regulation and nuclear architecture in malaria parasites |
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| Supervisor(s) |
| Artur Scherf |
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| University |
| University of Porto |
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| Laboratory |
| Institut Pasteur, Biology of Host-Parasite Interactions Unit |
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| City |
| Paris |
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| Country |
| France |
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| Date of Thesis Defence |
| 2009-01-30 |
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| After the PhD (Current Situation) |
| Position |
| Post-doctoral fellow |
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| Institution |
| Instituto de Medicina Molecular |
| View Institution website |
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| City |
| Lisboa |
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| Country |
| Portugal |
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| Relevant Publications |
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Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A.
Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites.
Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15117-22. |
| View Publication |
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Mancio-Silva L, Lopez-Rubio JJ, Claes A, Scherf A.
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.
Nat Commun. 2013;4:1530. doi: 10.1038/ncomms2539. |
| View Publication |
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Freitas-Junior LH, Hernandez-Rivas R, Ralph SA, Montiel-Condado D, Ruvalcaba-Salazar OK, Rojas-Meza AP, Mancio-Silva L, Leal-Silvestre RJ, Gontijo AM, Shorte S, Scherf A.
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.
Cell. 2005 Apr 8;121(1):25-36. |
| View Publication |
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Mancio-Silva L, Rojas-Meza AP, Vargas M, Scherf A, Hernandez-Rivas R.
Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum.
J Cell Sci. 2008 Jun 15;121(Pt 12):2046-53. |
| View Publication |
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Lopez-Rubio JJ*, Mancio-Silva L*, Scherf A.
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites.
Cell Host Microbe. 2009 Feb 19;5(2):179-90. *co-first authors |
| View Publication |
| Publications |
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Issar N, Ralph SA, Mancio-Silva L, Keeling C, Scherf A.
Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.
Microbes Infect. 2009 Mar;11(3):403-7. Epub 2008 Dec 27. |
| View Publication |
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Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Mancio-Silva L, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF.
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
PLoS Biol. 2009 Apr 14;7(4):e84. |
| View Publication |
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Pena AC, Penacho N, Mancio-Silva L, Neres R, Seixas JD, Fernandes AC, Romăo CC, Mota MM, Bernardes GJ, Pamplona A.
A novel Carbon Monoxide-Releasing Molecule (CO-RM) fully protects mice from Severe Malaria.
Antimicrob Agents Chemother. 2011 Dec 12. |
| View Publication |
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Ribot JC, Debarros A, Mancio-Silva L, Pamplona A, Silva-Santos B.
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
J Immunol. 2012 Aug 1;189(3):1202-8. doi: 10.4049/jimmunol.1200268. Epub 2012 Jun 25. |
| View Publication |
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Sierra-Miranda M, Delgadillo DM, Mancio-Silva L, Vargas M, Villegas-Sepulveda N, Martínez-Calvillo S, Scherf A, Hernandez-Rivas R.
Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum.
Mol Biochem Parasitol. 2012 Sep;185(1):36-47. doi: 10.1016/j.molbiopara.2012.06.005. Epub 2012 Jun 18. |
| View Publication |
[more publications]
| More Publications |
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Mancio-Silva L, Scherf A.
In situ fluorescence visualization of transcription sites and genomic Loci in blood stages of Plasmodium falciparum.
Methods Mol Biol. 2013;923:335-51. |
| View Publication |
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Figueiredo LM, Rocha EP, Mancio-Silva L, Prevost C, Hernandez-Verdun D, Scherf A.
The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus.
Nucleic Acids Res. 2005 Feb 18;33(3):1111-22. |
| View Publication |
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Pérez-Toledo K, Rojas-Meza AP, Mancio-Silva L, Hernández-Cuevas NA, Delgadillo DM, Vargas M, Martínez-Calvillo S, Scherf A, Hernandez-Rivas R.
Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes.
Nucleic Acids Res. 2009 Mar 6. |
| View Publication |
| Last Update |
| 2012-03-24 11:11:56 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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