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Class of 2003
Mancio-Silva, Liliana
1st Degree
About the PhD
Field of Research
Thesis Title
Gene regulation and nuclear architecture in malaria parasites
Artur Scherf
University of Porto
Institut Pasteur, Biology of Host-Parasite Interactions Unit
Date of Thesis Defence
After the PhD (Current Situation)
Post-doctoral fellow
Instituto de Medicina Molecular
View Institution website

Relevant Publications
Mancio-Silva L, Zhang Q, Scheidig-Benatar C, Scherf A.
Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites.
Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15117-22.
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Mancio-Silva L, Lopez-Rubio JJ, Claes A, Scherf A.
Sir2a regulates rDNA transcription and multiplication rate in the human malaria parasite Plasmodium falciparum.
Nat Commun. 2013;4:1530. doi: 10.1038/ncomms2539.
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Freitas-Junior LH, Hernandez-Rivas R, Ralph SA, Montiel-Condado D, Ruvalcaba-Salazar OK, Rojas-Meza AP, Mancio-Silva L, Leal-Silvestre RJ, Gontijo AM, Shorte S, Scherf A.
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasites.
Cell. 2005 Apr 8;121(1):25-36.
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Mancio-Silva L, Rojas-Meza AP, Vargas M, Scherf A, Hernandez-Rivas R.
Differential association of Orc1 and Sir2 proteins to telomeric domains in Plasmodium falciparum.
J Cell Sci. 2008 Jun 15;121(Pt 12):2046-53.
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Lopez-Rubio JJ*, Mancio-Silva L*, Scherf A.
Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites.
Cell Host Microbe. 2009 Feb 19;5(2):179-90. *co-first authors
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Issar N, Ralph SA, Mancio-Silva L, Keeling C, Scherf A.
Differential sub-nuclear localisation of repressive and activating histone methyl modifications in P. falciparum.
Microbes Infect. 2009 Mar;11(3):403-7. Epub 2008 Dec 27.
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Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Mancio-Silva L, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF.
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum.
PLoS Biol. 2009 Apr 14;7(4):e84.
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Pena AC, Penacho N, Mancio-Silva L, Neres R, Seixas JD, Fernandes AC, Romăo CC, Mota MM, Bernardes GJ, Pamplona A.
A novel Carbon Monoxide-Releasing Molecule (CO-RM) fully protects mice from Severe Malaria.
Antimicrob Agents Chemother. 2011 Dec 12.
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Ribot JC, Debarros A, Mancio-Silva L, Pamplona A, Silva-Santos B.
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
J Immunol. 2012 Aug 1;189(3):1202-8. doi: 10.4049/jimmunol.1200268. Epub 2012 Jun 25.
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Sierra-Miranda M, Delgadillo DM, Mancio-Silva L, Vargas M, Villegas-Sepulveda N, Martínez-Calvillo S, Scherf A, Hernandez-Rivas R.
Two long non-coding RNAs generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum.
Mol Biochem Parasitol. 2012 Sep;185(1):36-47. doi: 10.1016/j.molbiopara.2012.06.005. Epub 2012 Jun 18.
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Last Update
2012-03-24 11:11:56

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