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Class of 2003
Name
Casanova , Miguel
Nationality
Portuguese
E-Mail
miguel.casanova@curie.fr
About the PhD
Field of Research
Stem Cell & Epigenetics
Thesis Title
The role and regulation of Polycomb Group proteins in early development and Pluripotency
Abstract
Embryonic stem (ES) cells exist in a pluripotent state and have the ability to differentiate into all adult cell types. Numerous molecular mechanisms are responsible for both maintaining pluripotency and directing differentiation....
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Supervisor(s)
Neil Brockdorff
University
Imperial College of London
Laboratory
Developmental Epigenetics Group, MRC Clinical Sciences Centre
City
London
Country
United Kingdom
Date of Thesis Defence
2009-01-19
After the PhD (Current Situation)
Position
Postdoc
Project
Role of Major Satellite transcription in cellular reprogramming
Institution
Institut Curie
City
Paris
Country
France

Relevant Publications
A Strand-Specific Burst in Transcription of Pericentric Satellites Is Required for Chromocenter Formation and Early Mouse Development

Aline.V. Probst, Ikuhiro Okamoto, Miguel Casanova, Fatima El Marjou, Patricia Le Baccon, Geneviève Almouzni
View Publication
Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells

Miguel Casanova, Tanja Preissner, Andrea Cerase, Raymond Poot, Daisuke Yamada, Xiangzhi Li, Ruth Appanah, Karel Bezstarosti, Jeroen Demmers, Haruhiko Koseki and Neil Brockdorff
View Publication
Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

Julie K. Stock, Sara Giadrossi, Miguel Casanova, Emily Brookes, Miguel Vidal, Haruhiko Koseki, Neil Brockdorff, Amanda G. Fisher & Ana Pombo
View Publication

Publications
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators

Landeira D, Sauer S, Poot R, Dvorkina M, Mazzarella L, Jørgensen HF, Pereira CF, Leleu M, Piccolo FM, Spivakov M, Brookes E, Pombo A, Fisher C, Skarnes WC, Snoek T, Bezstarosti K, Demmers J, Klose RJ, Casanova M, Tavares L, Brockdorff N, Merkenschlager M, Fisher AG.
View Publication
Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.

Xiangzhi Li,1 Kyo-ichi Isono, Daisuke Yamada, Takaho A. Endo, Mitsuhiro Endoh, Jun Shinga, Yoko Mizutani-Koseki, Arie P. Otte, Miguel Casanova, Hiroshi Kitamura, Takehiko Kamijo, Jafar Sharif, Osamu Ohara, Tetsuro Toyada, Bradley E. Bernstein, Neil Brockdorff, and Haruhiko Koseki
View Publication
Polycomb Repressive Complexes Restrain the Expression of Lineage-Specific Regulators in Embryonic Stem Cells

Helle F. Jørgensen, Sara Giadrossi, Miguel Casanova, Mitsuhiro Endoh, Haruhiko Koseki, Neil Brockdorff and Amanda G. Fisher
View Publication
Chromatin signatures of pluripotent cell lines

Véronique Azuara, Pascale Perry, Stephan Sauer, Mikhail Spivakov, Helle F. Jørgensen, Rosalind M. John, Mina Gouti, Miguel Casanova, Gary Warnes, Matthias Merkenschlager & Amanda G. Fisher

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