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| Name |
| Reis, Rui Manuel |
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| Nationality |
| Portuguese |
| E-Mail |
| rreis@med.uminho.pt |
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| 1st Degree |
| Biology |
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| University (1st Degree) |
| University of Porto |
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| Master Degree |
| Biology |
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| About the PhD |
| Field of Research |
| Neuro-oncology |
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| Thesis Title |
| Genetic alterations associated with development of solid tumors |
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| Supervisor(s) |
| Paul Kleihues (IARC, Lyon, France); |
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| Co-Supervisor(s) |
| Hiroko Ohgaki (IARC, Lyon, France);Jose Manuel Lopes (IPATIMUP, Porto, Portugal) |
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| University |
| Porto |
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| Laboratory |
| International Agency for Research on Cancer (IARC) |
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| City |
| Lyon |
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| Country |
| France |
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| Date of Thesis Defence |
| 2002-03-01 |
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| After the PhD (Current Situation) |
| Position |
| Scientific Director |
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| Institution |
| Molecular Oncology Research Center, Barretos Cancer Hospital |
| View Institution website |
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| City |
| Barretos |
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| Country |
| Brazil |
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| Relevant Publications |
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| Goss PE, Lee BL, Badovinac-Crnjevic T, Strasser-Weippl K, Chavarri-Guerra Y, Louis JS, Villarreal-Garza C, Carvalho A, Gil CF, Sternberg C, Dueñas-Gonzalez A, Sgroi D, Cuello M, Fresco R, Reis RM, Villa L, Solares AL, Leon MX, Torres-Vigil I, Covarrubias-Gomez A, Hernández A, Bertolino M, Schwartsmann G, Santillana S, Esteva F, Fein L, Mano M, Gomez H, Hurlbert M, Durstine A, Azenha G. Planning cancer control in Latin America and the Caribbean. Lancet Oncol. 2013;14(5):391-436. |
| View Publication |
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Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer.
Pinto F, Pértega-Gomes N, Vizcaíno JR, Andrade RP, Cárcano FM, Reis RM.
Oncotarget. 2016 May 17;7(20):28891-902. |
| View Publication |
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Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker.
Silva-Oliveira RJ, Silva VA, Martinho O, Cruvinel-Carloni A, Melendez ME, Rosa MN, de Paula FE, de Souza Viana L, Carvalho AL, Reis RM.
Cell Oncol (Dordr). 2016 Jun;39(3):253-63. |
| View Publication |
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Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas.
Miranda-Gonçalves V, Granja S, Martinho O, Honavar M, Pojo M, Costa BM, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Reis RM, Baltazar F.
Oncotarget. 2016 Jul 19;7(29):46335-46353 |
| View Publication |
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Copy Number Profiling of Brazilian Astrocytomas.
Bidinotto LT, Torrieri R, Mackay A, Almeida GC, Viana-Pereira M, Cruvinel-Carloni A, Spina ML, Campanella NC, Pereira de Menezes W, Clara CA, Becker AP, Jones C, Reis RM.
G3 (Bethesda). 2016 Jul 7;6(7):1867-78. |
| View Publication |
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The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism.
Batista R, Cruvinel-Carloni A, Vinagre J, Peixoto J, Catarino TA, Campanella NC, Menezes W, Becker AP, de Almeida GC, Matsushita MM, Clara C, Neder L, Viana-Pereira M, Honavar M, Castro L, Lopes JM, Carvalho B, Vaz RM, Máximo V, Soares P, Sobrinho-Simões M, Reis RM, Lima J.
Int J Cancer. 2016 Jul 15;139(2):414-23. |
| View Publication |
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| TCGA Research Network. Bass AJ, Derks S, Thorsson V, Shmulevich I, Dhankani V, Miller M, Hinoue T, Laird PW, Shen H, Schultz N, Shen R, Getz G, Lander E, Carvalho AL, Reis RM, Matsushita MM, Lucchesi F, de Oliveira AT, Janjigian Y, Kelsen D, Ladanyi M, Tang L, McCall SJ, Cheong JH, Ajani JA, Camargo CM. Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Demchok JA, Felau I, Ferguson ML, Mills Shaw, Sheth M, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Hutter CM, Sofia HJ, Zhang J. Comprehensive Molecular Characterization of Oesophageal Carcinoma. Nature 2017 ;541(7636):169-175. |
| View Publication |
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HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors.
Martinho O, Silva-Oliveira R, Cury FP, Barbosa AM, Granja S, Evangelista AF, Marques F, Miranda-Gonçalves V, Cardoso-Carneiro D, de Paula FE, Zanon M, Scapulatempo-Neto C, Moreira MA, Baltazar F, Longatto-Filho A, Reis RM.
Theranostics. 2017 Jan 15;7(3):717-732. doi: 10.7150/thno.17154. eCollection 2017. |
| View Publication |
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Study of hTERT and Histone 3 Mutations in Medulloblastoma.
Viana-Pereira M, Almeida GC, Stavale JN, Malheiro S, Clara C, Lobo P, Pimentel J, Reis RM.
Pathobiology. 2017;84(2):108-113. |
| View Publication |
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Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells.
Faião-Flores F, Alves-Fernandes DK, Pennacchi PC, Sandri S, Vicente AL, Scapulatempo-Neto C, Vazquez VL, Reis RM, Chauhan J, Goding CR, Smalley KS, Maria-Engler SS.
Oncogene. 2017 Mar 30;36(13):1849-1861. |
| View Publication |
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Mutational profile of TP53 in esophageal squamous cell carcinoma associated with chagasic megaesophagus.
Lacerda CF, Cruvinel-Carloni A, de Oliveira AT, Scapulatempo-Neto C, López RV, Crema E, Adad SJ, Rodrigues MA, Henry MA, Guimarães DP, Reis RM.
Dis Esophagus. 2017 Apr 1;30(4):1-9 |
| View Publication |
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| AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors. Silva-Oliveira RJ, Melendez M, Martinho O, Zanon MF, de Souza Viana L, Carvalho AL, Reis RM. Oncotarget. 2017 Jun 7;8(32):53288-53301 |
| View Publication |
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| Mackay A, Burford A, Carvalho D, Izquierdo E, Fazal-Salom J, Taylor KR, Bjerke L, Clarke M, Vinci M, Nandhabalan M, Temelso S, Popov S, Molinari V, Raman P, Waanders AJ, Han HJ, Gupta S, Al-Sarraj S, Chandler C, Ng HK, Li X, Mu K, Trabelsi S, Brahim DH, Kisljakov AN, Konovalov DM, Moore AS, Carcaboso AM, Sunol M, de Torres C, Cruz O, Mora J, Shats LI, Stavale JN, Bidinotto LT, Reis RM, Entz-Werle N, Farrell M, Cryan J, Crimmins D, Caird J, Pears J, Monje M, Jabado N, Baker SJ, Pfister SM, Jones DTW, Fouladi M, von Bueren AO, Baudis M, Resnick A, Jones C. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. Cancer Cell. 2017 Oct 9;32(4):520-537.e5. |
| View Publication |
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Expression of tyrosine kinase receptor AXL is associated with worse outcome of metastatic renal cell carcinomas treated with sunitinib.
Zucca LE, Morini Matushita MA, da Silva Oliveira RJ, Scapulatempo-Neto C, de Lima MA, Ribeiro GG, Viana CR, Cárcano FM, Reis RM.
Urol Oncol. 2017 Oct 3. pii: S1078-1439(17)30466-0. doi: 10.1016/j.urolonc.2017.09.003. [Epub ahead of print] |
| View Publication |
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| Reis RM, Könü-Lebleblicioglu D, Lopes JM, Kleihues P, Ohgaki H. Genetic profile of the gliosarcoma. American Journal Pathology, 2000, 156:425-432. |
| View Publication |
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| Basto D, Trovisco V, Lopes JM, Martins A, Pardal F, Soares P, Reis RM. Mutation analysis of B-RAF gene in human gliomas. Acta Neuropathologica, 2005, 109(2):207-10. |
| View Publication |
| Publications |
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SPINT2 Deregulation in Prostate Carcinoma.
Pereira MS, de Almeida GC, Pinto F, Viana-Pereira M, Reis RM.
J Histochem Cytochem. 2016 Jan;64(1):32-41. |
| View Publication |
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TERT promoter mutations in soft tissue sarcomas.
Campanella NC, Penna V, Abrahão-Machado LF, Cruvinel-Carloni A, Ribeiro G, Soares P, Scapulatempo-Neto C, Reis RM.
Int J Biol Markers. 2016 Feb 28;31(1):e62-7 |
| View Publication |
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Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer.
Jezkova J, Williams JS, Pinto F, Sammut SJ, Williams GT, Gollins S, McFarlane RJ, Reis RM, Wakeman JA.
Oncotarget. 2016 Mar 8;7(10):11478-86 |
| View Publication |
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Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas.
Vazquez Vde L, Vicente AL, Carloni A, Berardinelli G, Soares P, Scapulatempo C, Martinho O, Reis RM.
Melanoma Res. 2016 Apr;26(2):93-9. |
| View Publication |
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Hotspot TERT promoter mutations are rare events in testicular germ cell tumors.
Cárcano FM, Vidal DO, van Helvoort Lengert A, Neto CS, Queiroz L, Marques H, Baltazar F, da Silva Martinelli CM, Soares P, da Silva EC, Lopes LF, Reis RM.
Tumour Biol. 2016 Apr;37(4):4901-7 |
| View Publication |
[more publications]
| More Publications |
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Oncogenetics service and the Brazilian public health system: the experience of a reference Cancer Hospital.
Palmero EI, Galvão HC, Fernandes GC, Paula AE, Oliveira JC, Souza CP, Andrade CE, Romagnolo LG, Volc S, C Neto M, Sabato C, Grasel R, Mauad E, Reis RM, Michelli RA.
Genet Mol Biol. 2016 May 13;39(2):168-77 |
| View Publication |
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Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas.
Martinho O, Campos M, Ribeiro G, Penna V, Curcelli EC, Olivieri MV, Morini S, Scapulatempo C, Abrahão-Machado LF, Reis RM.
Pathobiology. 2016;83(1):41-6. |
| View Publication |
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The metabolic microenvironment of melanomas: Prognostic value of MCT1 and MCT4.
Pinheiro C, Miranda-Gonçalves V, Longatto-Filho A, Vicente AL, Berardinelli GN, Scapulatempo-Neto C, Costa RF, Viana CR, Reis RM, Baltazar F, Vazquez VL.
Cell Cycle. 2016 Jun 2;15(11):1462-70. |
| View Publication |
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Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis.
Martins SF, Amorim R, Viana-Pereira M, Pinheiro C, Costa RF, Silva P, Couto C, Alves S, Fernandes S, Vilaça S, Falcão J, Marques H, Pardal F, Rodrigues M, Preto A, Reis RM, Longatto-Filho A, Baltazar F.
BMC Cancer. 2016 Jul 26;16:535 |
| View Publication |
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Tumor Growth Suppression Induced by Biomimetic Silk Fibroin Hydrogels.
Yan LP, Silva-Correia J, Ribeiro VP, Miranda-Gonçalves V, Correia C, da Silva Morais A, Sousa RA, Reis RM, Oliveira AL, Oliveira JM, Reis RL.
Sci Rep. 2016 Aug 3;6:31037. |
| View Publication |
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Lactate Transporters and pH Regulation: Potential Therapeutic Targets in Glioblastomas.
Miranda-Gonçalves V, Reis RM, Baltazar F.
Curr Cancer Drug Targets. 2016;16(5):388-99. Review. |
| View Publication |
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A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.
Ríos-Tamayo R, Lupiañez CB, Campa D, Hielscher T, Weinhold N, Martínez-López J, Jerez A, Landi S, Jamroziak K, Dumontet C, Wątek M, Lesueur F, Reis RM, Marques H, Jurczyszyn A, Vogel U, Buda G, García-Sanz R, Orciuolo E, Petrini M, Vangsted AJ, Gemignani F, Försti A, Goldschmidt H, Hemminki K, Canzian F, Jurado M, Sainz J.
Oncotarget. 2016 Sep 13;7(37):59029-59048 |
| View Publication |
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31.
Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation.
Sandri S, Faião-Flores F, Tiago M, Pennacchi PC, Massaro RR, Alves-Fernandes DK, Berardinelli GN, Evangelista AF, de Lima Vazquez V, Reis RM, Maria-Engler SS.
Pharmacol Res. 2016 Sep;111:523-533. |
| View Publication |
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Isolation, characterization and screening of the in vitro cytotoxic activity of a novel L-amino acid oxidase (LAAOcdt) from Crotalus durissus terrificus venom on human cancer cell lines.
Teixeira TL, Oliveira Silva VA, da Cunha DB, Polettini FL, Thomaz CD, Pianca AA, Zambom FL, da Silva Leitão Mazzi DP, Reis RM, Mazzi MV.
Toxicon. 2016 Sep 1;119:203-17. |
| View Publication |
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Absence of microsatellite instability and BRAF (V600E) mutation in testicular germ cell tumors.
Cárcano FM, Lengert AH, Vidal DO, Scapulatempo Neto C, Queiroz L, Marques H, Baltazar F, Berardinelli GN, Martinelli CM, da Silva EC, Reis RM, Lopes LF.
Andrology. 2016 Sep;4(5):866-72. |
| View Publication |
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Anti-EGFR Therapy: Strategies in Head and Neck Squamous Cell Carcinoma.
Oliveira-Silva RJ, Carolina de Carvalho A, de Souza Viana L, Carvalho AL, Reis RM.
Recent Pat Anticancer Drug Discov. 2016;11(2):170-83. |
| View Publication |
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Low mutation percentage of KRAS and BRAF genes in Brazilian anal tumors.
Bidinotto LT, Véo CA, Loaiza EA, De França AP, Lorenzi AT, Rosa LA, De Oliveira CM, Levi JE, Scapulatempo-Neto C, Longatto-Filho A, Reis RM.
Mol Med Rep. 2016 Oct;14(4):3791-7. |
| View Publication |
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Tapirira guianensis Aubl. Extracts Inhibit Proliferation and Migration of Oral Cancer Cells Lines.
Silva-Oliveira RJ, Lopes GF, Camargos LF, Ribeiro AM, Santos FV, Severino RP, Severino VG, Terezan AP, Thomé RG, Santos HB, Reis RM, Ribeiro RI.
Int J Mol Sci. 2016 Nov 8;17(11). pii: E1839. |
| View Publication |
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Racial/Ethnic Disparities in Cervical Cancer Screening and Outcomes.
Musselwhite LW, Oliveira CM, Kwaramba T, de Paula Pantano N, Smith JS, Fregnani JH, Reis RM, Mauad E, Vazquez FL, Longatto-Filho A.
Acta Cytol. 2016;60(6):518-526. Epub 2016 Nov 9. Review. |
| View Publication |
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MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib.
Bordinhão AL, Evangelista AF, Oliveira RJ, Macedo T, Silveira HC, Reis RM, Marques MM.
Oncol Rep. 2016 Dec;36(6):3197-3206. |
| View Publication |
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24.
Prevalence of BRCA1/BRCA2 mutations in a Brazilian population sample at-risk for hereditary breast cancer and characterization of its genetic ancestry.
Fernandes GC, Michelli RA, Galvão HC, Paula AE, Pereira R, Andrade CE, Felicio PS, Souza CP, Mendes DR, Volc S, Berardinelli GN, Grasel RS, Sabato CS, Viana DV, Mauad EC, Scapulatempo-Neto C, Arun B, Reis RM, Palmero EI.
Oncotarget. 2016 Dec 6;7(49):80465-80481. |
| View Publication |
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Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis.
Xavier-Magalhães A, Oliveira AI, de Castro JV, Pojo M, Gonçalves CS, Lourenço T, Viana-Pereira M, Costa S, Linhares P, Vaz R, Nabiço R, Amorim J, Pinto AA, Reis RM, Costa BM.
J Neurooncol. 2017 Mar;132(1):27-34. |
| View Publication |
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Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString technology.
Evangelista AF, Zanon MF, Carloni AC, de Paula FE, Morini MA, Ferreira-Neto M, Soares IC, Miziara JE, de Marchi P, Scapulatempo-Neto C, Reis RM.
BMC Pulm Med. 2017 May 26;17(1):86. |
| View Publication |
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| Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk. Miranda-Gonçalves V, Bezerra F, Costa-Almeida R, Freitas-Cunha M, Soares R, Martinho O, Reis RM, Pinheiro C, Baltazar F. Mol Carcinog. 2017 Aug 1. doi: 10.1002/mc.22707 |
| View Publication |
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A survey of the clinicopathological and molecular characteristics of patients with suspected Lynch syndrome in Latin America.
Rossi BM, Palmero EI, López-Kostner F, Sarroca C, Vaccaro CA, Spirandelli F, Ashton-Prolla P, Rodriguez Y, de Campos Reis Galvão H, Reis RM, Escremim de Paula A, Capochin Romagnolo LG, Alvarez K, Della Valle A, Neffa F, Kalfayan PG, Spirandelli E, Chialina S, Gutiérrez Angulo M, Castro-Mujica MDC, Sanchez de Monte J, Quispe R, da Silva SD, Rossi NT, Barletta-Carrillo C, Revollo S, Taborga X, Morillas LL, Tubeuf H, Monteiro-Santos EM, Piñero TA, Dominguez-Barrera C, Wernhoff P, Martins A, Hovig E, Møller P, Dominguez-Valentin M.
BMC Cancer. 2017 Sep 5;17(1):623. doi: 10.1186/s12885-017-3599-4. |
| View Publication |
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| Alginate hydrogel improves anti-angiogenic bevacizumab activity in cancer therapy. Ferreira NN, M B Ferreira L, Miranda-Gonçalves V, Reis RM, Seraphim TV, Borges JC, Baltazar F, Gremião MPD. Eur J Pharm Biopharm. 2017 Oct;119:271-282. |
| View Publication |
| Last Update |
| 2020-04-14 21:47:02 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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