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Class of 1996
Name
Reis, Rui Manuel
Nationality
Portuguese
E-Mail
rreis@ecsaude.uminho.pt
1st Degree
Biology
University (1st Degree)
University of Porto
Master Degree
Biology
About the PhD
Field of Research
Neuro-oncology
Thesis Title
Genetic alterations associated with development of solid tumors
Supervisor(s)
Paul Kleihues (IARC, Lyon, France);
Co-Supervisor(s)
Hiroko Ohgaki (IARC, Lyon, France);Jose Manuel Lopes (IPATIMUP, Porto, Portugal)
University
Porto
Laboratory
International Agency for Research on Cancer (IARC)
City
Lyon
Country
France
Date of Thesis Defence
2002-03-01
After the PhD (Current Situation)
Position
Scientific Director
Institution
Molecular Oncology Research Center, Barretos Cancer Hospital
View Institution website
City
Barretos
Country
Brazil

Relevant Publications
Goss PE, Lee BL, Badovinac-Crnjevic T, Strasser-Weippl K, Chavarri-Guerra Y, Louis JS, Villarreal-Garza C, Carvalho A, Gil CF, Sternberg C, Dueñas-Gonzalez A, Sgroi D, Cuello M, Fresco R, Reis RM, Villa L, Solares AL, Leon MX, Torres-Vigil I, Covarrubias-Gomez A, Hernández A, Bertolino M, Schwartsmann G, Santillana S, Esteva F, Fein L, Mano M, Gomez H, Hurlbert M, Durstine A, Azenha G. Planning cancer control in Latin America and the Caribbean. Lancet Oncol. 2013;14(5):391-436.
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Brachyury as a potential modulator of androgen receptor activity and a key player in therapy resistance in prostate cancer.
Pinto F, Pértega-Gomes N, Vizcaíno JR, Andrade RP, Cárcano FM, Reis RM.
Oncotarget. 2016 May 17;7(20):28891-902.
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Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker.
Silva-Oliveira RJ, Silva VA, Martinho O, Cruvinel-Carloni A, Melendez ME, Rosa MN, de Paula FE, de Souza Viana L, Carvalho AL, Reis RM.
Cell Oncol (Dordr). 2016 Jun;39(3):253-63.
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Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas.
Miranda-Gonçalves V, Granja S, Martinho O, Honavar M, Pojo M, Costa BM, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Reis RM, Baltazar F.
Oncotarget. 2016 Jul 19;7(29):46335-46353
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Copy Number Profiling of Brazilian Astrocytomas.
Bidinotto LT, Torrieri R, Mackay A, Almeida GC, Viana-Pereira M, Cruvinel-Carloni A, Spina ML, Campanella NC, Pereira de Menezes W, Clara CA, Becker AP, Jones C, Reis RM.
G3 (Bethesda). 2016 Jul 7;6(7):1867-78.
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The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism.
Batista R, Cruvinel-Carloni A, Vinagre J, Peixoto J, Catarino TA, Campanella NC, Menezes W, Becker AP, de Almeida GC, Matsushita MM, Clara C, Neder L, Viana-Pereira M, Honavar M, Castro L, Lopes JM, Carvalho B, Vaz RM, Máximo V, Soares P, Sobrinho-Simões M, Reis RM, Lima J.
Int J Cancer. 2016 Jul 15;139(2):414-23.
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TCGA Research Network. Bass AJ, Derks S, Thorsson V, Shmulevich I, Dhankani V, Miller M, Hinoue T, Laird PW, Shen H, Schultz N, Shen R, Getz G, Lander E, Carvalho AL, Reis RM, Matsushita MM, Lucchesi F, de Oliveira AT, Janjigian Y, Kelsen D, Ladanyi M, Tang L, McCall SJ, Cheong JH, Ajani JA, Camargo CM. Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Demchok JA, Felau I, Ferguson ML, Mills Shaw, Sheth M, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Hutter CM, Sofia HJ, Zhang J. Comprehensive Molecular Characterization of Oesophageal Carcinoma. Nature 2017 ;541(7636):169-175.
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HER Family Receptors are Important Theranostic Biomarkers for Cervical Cancer: Blocking Glucose Metabolism Enhances the Therapeutic Effect of HER Inhibitors.
Martinho O, Silva-Oliveira R, Cury FP, Barbosa AM, Granja S, Evangelista AF, Marques F, Miranda-Gonçalves V, Cardoso-Carneiro D, de Paula FE, Zanon M, Scapulatempo-Neto C, Moreira MA, Baltazar F, Longatto-Filho A, Reis RM.
Theranostics. 2017 Jan 15;7(3):717-732. doi: 10.7150/thno.17154. eCollection 2017.
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Study of hTERT and Histone 3 Mutations in Medulloblastoma.
Viana-Pereira M, Almeida GC, Stavale JN, Malheiro S, Clara C, Lobo P, Pimentel J, Reis RM.
Pathobiology. 2017;84(2):108-113.
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Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells.
Faião-Flores F, Alves-Fernandes DK, Pennacchi PC, Sandri S, Vicente AL, Scapulatempo-Neto C, Vazquez VL, Reis RM, Chauhan J, Goding CR, Smalley KS, Maria-Engler SS.
Oncogene. 2017 Mar 30;36(13):1849-1861.
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Mutational profile of TP53 in esophageal squamous cell carcinoma associated with chagasic megaesophagus.
Lacerda CF, Cruvinel-Carloni A, de Oliveira AT, Scapulatempo-Neto C, López RV, Crema E, Adad SJ, Rodrigues MA, Henry MA, Guimarães DP, Reis RM.
Dis Esophagus. 2017 Apr 1;30(4):1-9
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AKT can modulate the in vitro response of HNSCC cells to irreversible EGFR inhibitors. Silva-Oliveira RJ, Melendez M, Martinho O, Zanon MF, de Souza Viana L, Carvalho AL, Reis RM. Oncotarget. 2017 Jun 7;8(32):53288-53301
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Mackay A, Burford A, Carvalho D, Izquierdo E, Fazal-Salom J, Taylor KR, Bjerke L, Clarke M, Vinci M, Nandhabalan M, Temelso S, Popov S, Molinari V, Raman P, Waanders AJ, Han HJ, Gupta S, Al-Sarraj S, Chandler C, Ng HK, Li X, Mu K, Trabelsi S, Brahim DH, Kisljakov AN, Konovalov DM, Moore AS, Carcaboso AM, Sunol M, de Torres C, Cruz O, Mora J, Shats LI, Stavale JN, Bidinotto LT, Reis RM, Entz-Werle N, Farrell M, Cryan J, Crimmins D, Caird J, Pears J, Monje M, Jabado N, Baker SJ, Pfister SM, Jones DTW, Fouladi M, von Bueren AO, Baudis M, Resnick A, Jones C. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. Cancer Cell. 2017 Oct 9;32(4):520-537.e5.
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Expression of tyrosine kinase receptor AXL is associated with worse outcome of metastatic renal cell carcinomas treated with sunitinib.
Zucca LE, Morini Matushita MA, da Silva Oliveira RJ, Scapulatempo-Neto C, de Lima MA, Ribeiro GG, Viana CR, Cárcano FM, Reis RM.
Urol Oncol. 2017 Oct 3. pii: S1078-1439(17)30466-0. doi: 10.1016/j.urolonc.2017.09.003. [Epub ahead of print]
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Reis RM, Könü-Lebleblicioglu D, Lopes JM, Kleihues P, Ohgaki H. Genetic profile of the gliosarcoma. American Journal Pathology, 2000, 156:425-432.
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Basto D, Trovisco V, Lopes JM, Martins A, Pardal F, Soares P, Reis RM. Mutation analysis of B-RAF gene in human gliomas. Acta Neuropathologica, 2005, 109(2):207-10.
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Publications
SPINT2 Deregulation in Prostate Carcinoma.
Pereira MS, de Almeida GC, Pinto F, Viana-Pereira M, Reis RM.
J Histochem Cytochem. 2016 Jan;64(1):32-41.
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TERT promoter mutations in soft tissue sarcomas.
Campanella NC, Penna V, Abrahão-Machado LF, Cruvinel-Carloni A, Ribeiro G, Soares P, Scapulatempo-Neto C, Reis RM.
Int J Biol Markers. 2016 Feb 28;31(1):e62-7
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Brachyury identifies a class of enteroendocrine cells in normal human intestinal crypts and colorectal cancer.
Jezkova J, Williams JS, Pinto F, Sammut SJ, Williams GT, Gollins S, McFarlane RJ, Reis RM, Wakeman JA.
Oncotarget. 2016 Mar 8;7(10):11478-86
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Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas.
Vazquez Vde L, Vicente AL, Carloni A, Berardinelli G, Soares P, Scapulatempo C, Martinho O, Reis RM.
Melanoma Res. 2016 Apr;26(2):93-9.
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Hotspot TERT promoter mutations are rare events in testicular germ cell tumors.
Cárcano FM, Vidal DO, van Helvoort Lengert A, Neto CS, Queiroz L, Marques H, Baltazar F, da Silva Martinelli CM, Soares P, da Silva EC, Lopes LF, Reis RM.
Tumour Biol. 2016 Apr;37(4):4901-7
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[more publications]
Last Update
2017-10-14 05:27:16

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