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Class of 2004
Name
Nóbrega, Cláudia
E-Mail
crnobrega@gmail.com
1st Degree
Biochemistry
About the PhD
Field of Research
Immunology of Infection
Thesis Title
Infection of the thymus by mycobacteria: potential impact on the immune response to infection
Supervisor(s)
Margarida Correia-Neves
Co-Supervisor(s)
Rui Appelberg
University
Instituto de Ciencias Biomédicas Abel Salazar (ICBAS), University of Porto
Laboratory
Infection and Immunology Laboratory, Institute for Molecular and Cell Biology (IBMC)
City
Porto
Country
Portugal
Date of Thesis Defence
2009-06-01
After the PhD (Current Situation)
Position
Posdoctoral fellow
Project
Characterization of T cells in HIV+ patients co-infected with tuberculosis
Institution
Life and Health Sciences Research Institute
View Institution website
City
Braga
Country
Portugal

Relevant Publications
Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen
C. Nobrega, S. Roque, C. Nunes-Alves, A. Coelho, I. Medeiros, A. G. Castro, R. Appelberg, M. Correia-Neves
Journal of Immunology, 2010, 184: 351
doi:10.4049/jimmunol.0902152
View Publication
A case-control study on the diagnostic potential of multi-antigen serological tests for tuberculosis
R. Duarte, A. Afonso, C. Ferreira, S. Roque, O. Vasconcelos, R. Sarmento-Castro, M. Tavares, C. Caldas, R. Greenwald, K. Lyashchenko, M. Correia-Neves, C. Nobrega
Archives of Clinical Microbiology, 2012, 3(2): 1-5
doi: 10.3823/249
View Publication
T cells home to the thymus and control infection
C. Nobrega*, C. Nunes-Alves*, B. Cerqueira-Rodrigues, S. Roque, P. Barreira-Silva, S. M. Behar, M. Correia-Neves
*These authors have equally contributed to this work
Journal of Immunology, 2013, 190:1646
doi:10.4049/jimmunol.1202412
High percentage of regulatory CD4+ T cells associates with worse immune reconstitution in HIV-infected patients
A. Horta*, C. Nobrega*, P. Amorim-Machado, V. Coutinho-Teixeira, P. Barreira-Silva, S. Boavida, P. Costa, R. Sarmento-Castro, A. Gil Castro, M. Correia-Neves
*These authors have equally contributed to this work
PLoS ONE, 2013, 8(2):e257336
doi:10.1371/journal.pone.005733
Tolerance has its limits: how the thymus copes with infection
C. Nunes-Alves, C. Nobrega, S. Behar, M. Correia-Neves
Trends in Immunology, 2013
doi 10.1016/j.it.2013.06.004
The thymus as a target for mycobacterial infections
C. Nobrega, P.-J. Cardona, S. Roquea, P. Pinto do Ó, R. Appelberg, M. Correia-Neves
Microbes and Infection, 2007, 9 (14-15): 1521
View Publication

Publications
Environmental Enrichment does not Compromise the Immune Response in Mice Chronically Infected with Mycobacterium avium
A. Olsson, A. Costa, C. Nobrega, S. Roque, M. Correia-Neves
Scandinavian Journal of Immunology, 2010, 71(4): 249
doi: 10.1111/j.1365-3083.2010.02371.x
View Publication
Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration
S. Roque, T. Gil Oliveira, C. Nobrega, P. Barreira-Silva, C. Nunes-Alves, N. Sousa, J. Almeida Palha, M. Correia-Neves
Frontiers in Behavioral Neurosciences, 2011, 5: 4
doi: 10.3389/fnbeh.2011.00004
View Publication
Lipoarabinomannan mannose caps do not affect mycobacterial virulence and immunogenicity in experimental animal models of infection
A. Afonso-Barroso, S.O. Clark, A. Williams, G.T. Rosa, C. Nobrega, S. Silva-Gomes, S. Vale-Costa, R. Ummels, N. Stoker, F.M. Zadeh, P. van der Ley, B.J. Appelmelk, G. Puzo, J. Nigou, J. Geurtsen, R. Appelberg
Cellular Microbiology, 2013, 15(4): 660
doi:10.1111/cmi.12065
A bacteriophage detection tool for viability assessment of Salmonella cells
E. Fernandes, V. Martins, C. Nobrega, C. M. Carvalho, F. A. Cardoso, S. Cardoso, J. Dias, D. Deng, L. D. Kluskens, P. P. Freitas, J. Azeredo
Biosensors and Bioelectronics (Accepted for publication)
IL-10 Underlies Distinct Susceptibility of BALB/c and C57BL/6 Mice to Mycobacterium avium Infection and Influences Efficacy of Antibiotic Therapy
S. Roque, C. Nobrega, R. Appelberg, M. Correia-Neves
The Journal of Immunology, 2007, 178: 8028
View Publication
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology