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Class of 2004
Name
Simões Correia, Joana
Nationality
Portuguese
E-Mail
simoes.correia@gmail.com
1st Degree
Biological Chemistry
University (1st Degree)
University of Coimbra, Portugal
About the PhD
Field of Research
Human Biology
Thesis Title
The role of E-cadherin trafficking deregulation in epithelial cancer progression
Supervisor(s)
Gianpaolo Suriano
Co-Supervisor(s)
Raquel Seruca, Frans van Roy
University
Faculty of Medicine, University of Porto, Portugal
Laboratory
Cancer Genetics - IPATIMUP, Portugal; Molecular and Cellular Biology Unit - VIB, Gent, Belgium; Systems Biology - CRG, Barcelona, Spain
City
Porto
Country
Portugal
Date of Thesis Defence
2009-05-04
After the PhD (Current Situation)
Position
Postdoc
Project
The role of Protein Quality Control in cancer
Institution
IPATIMUP - Porto and IBILI - Coimbra
View Institution website
City
Porto
Country
Portugal

Relevant Publications
Caldeira J, Simoes-Correia J, Paredes J, Pinto MT, Sousa S, et al. (2012) CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach. Gut 61: 1115-1123.
Simoes-Correia J, Figueiredo J, Lopes R, Stricher F, Oliveira C, et al. (2012) E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer. PLoS One 7: e33783.
Vogelaar IP, Figueiredo J, van Rooij IA, Simoes-Correia J, van der Post RS, et al. (2013) Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts. Hum Mol Genet 22: 919-926.
Simoes-Correia, J., et al., Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer. Hum Mol Genet, 2008. 17(22): p. 3566-76.
View Publication
Bajpai S, Correia J, Feng Y, Figueiredo J, Sun SX, et al. (2008) {alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proc Natl Acad Sci U S A 105: 18331-18336.

Publications
Mateus AR, Simoes-Correia J, Figueiredo J, Heindl S, Alves CC, et al. (2009) E-cadherin mutations and cell motility: a genotype-phenotype correlation. Exp Cell Res 315: 1393-1402.
Figueiredo J, Simoes-Correia J, Soderberg O, Suriano G, Seruca R (2011) ADP-ribosylation factor 6 mediates E-cadherin recovery by chemical chaperones. PLoS One 6: e23188.
Kluijt I, Siemerink EJ, Ausems MG, van Os TA, de Jong D, et al. (2012) CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. Int J Cancer 131: 367-376.
Sanghera N, Correia BE, Correia JR, Ludwig C, Agarwal S, et al. (2011) Deciphering the molecular details for the binding of the prion protein to main ganglioside GM1 of neuronal membranes. Chem Biol 18: 1422-1431.
Garziera M, De Re V, Geremia S, Seruca R, Figueiredo J, et al. (2012) A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy. Clin Exp Med.

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Last Update
2013-05-03 15:14:00

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