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| Name |
| Simões Correia, Joana |
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| Nationality |
| Portuguese |
| E-Mail |
| simoes.correia@gmail.com |
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| 1st Degree |
| Biological Chemistry |
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| University (1st Degree) |
| University of Coimbra, Portugal |
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| About the PhD |
| Field of Research |
| Human Biology |
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| Thesis Title |
| The role of E-cadherin trafficking deregulation in epithelial cancer progression |
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| Supervisor(s) |
| Gianpaolo Suriano |
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| Co-Supervisor(s) |
| Raquel Seruca, Frans van Roy |
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| University |
| Faculty of Medicine, University of Porto, Portugal |
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| Laboratory |
| Cancer Genetics - IPATIMUP, Portugal; Molecular and Cellular Biology Unit - VIB, Gent, Belgium; Systems Biology - CRG, Barcelona, Spain |
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| City |
| Porto |
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| Country |
| Portugal |
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| Date of Thesis Defence |
| 2009-05-04 |
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| After the PhD (Current Situation) |
| Position |
| Postdoc |
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| Project |
| The role of Protein Quality Control in cancer |
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| Institution |
| IPATIMUP - Porto and IBILI - Coimbra |
| View Institution website |
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| City |
| Porto |
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| Country |
| Portugal |
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| Relevant Publications |
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| Caldeira J, Simoes-Correia J, Paredes J, Pinto MT, Sousa S, et al. (2012) CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach. Gut 61: 1115-1123. |
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| Simoes-Correia J, Figueiredo J, Lopes R, Stricher F, Oliveira C, et al. (2012) E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer. PLoS One 7: e33783. |
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| Vogelaar IP, Figueiredo J, van Rooij IA, Simoes-Correia J, van der Post RS, et al. (2013) Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts. Hum Mol Genet 22: 919-926. |
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| Simoes-Correia, J., et al., Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer. Hum Mol Genet, 2008. 17(22): p. 3566-76. |
| View Publication |
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| Bajpai S, Correia J, Feng Y, Figueiredo J, Sun SX, et al. (2008) {alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proc Natl Acad Sci U S A 105: 18331-18336. |
| Publications |
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| Mateus AR, Simoes-Correia J, Figueiredo J, Heindl S, Alves CC, et al. (2009) E-cadherin mutations and cell motility: a genotype-phenotype correlation. Exp Cell Res 315: 1393-1402. |
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| Figueiredo J, Simoes-Correia J, Soderberg O, Suriano G, Seruca R (2011) ADP-ribosylation factor 6 mediates E-cadherin recovery by chemical chaperones. PLoS One 6: e23188. |
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| Kluijt I, Siemerink EJ, Ausems MG, van Os TA, de Jong D, et al. (2012) CDH1-related hereditary diffuse gastric cancer syndrome: clinical variations and implications for counseling. Int J Cancer 131: 367-376. |
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| Sanghera N, Correia BE, Correia JR, Ludwig C, Agarwal S, et al. (2011) Deciphering the molecular details for the binding of the prion protein to main ganglioside GM1 of neuronal membranes. Chem Biol 18: 1422-1431. |
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| Garziera M, De Re V, Geremia S, Seruca R, Figueiredo J, et al. (2012) A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy. Clin Exp Med. |
[more publications]
| More Publications |
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| Paredes J, Figueiredo J, Albergaria A, Oliveira P, Carvalho J, et al. (2012) Epithelial E- and P-cadherins: role and clinical significance in cancer. Biochim Biophys Acta 1826: 297-311. |
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| Carneiro P, Fernandes MS, Figueiredo J, Caldeira J, Carvalho J, et al. (2012) E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions. FEBS Lett 586: 2981-2989. |
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| Figueiredo J, Soderberg O, Simoes-Correia J, Grannas K, Suriano G, et al. (2013) The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC. Eur J Hum Genet 21: 301-309. |
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| Simões-Correia J, Mateus AR, Seruca R, Suriano G (2008) Experimental Gastric Cancer. In Management of Gastric Cancer: Recent Advances, Degiuli M (ed), Part II: Molecular Biology and Genetics, pp 37-44. Turin: Edizioni Minerva Medica |
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| Corso G, Roviello F, Paredes J, Pedrazzani C, Novais M, Correia J, Marrelli D, Cirnes L, Seruca R, Oliveira C, Suriano G (2007) Characterization of the P373L E-cadherin germline missense mutation and implication for clinical management. Eur J Surg Oncol 33(9): 1061-1067 |
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| Suriano G, Ferreira P, Mateus AR, Correia J, Henriques L, Seruca R (2006) Genetics of hereditary diffuse gastric cancer: progress and future challenges. Future Oncol 2(3): 363-370 |
| Last Update |
| 2013-05-03 15:14:00 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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