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Class of 2004
Name
Karam, Rachid
Nationality
Brazilian
E-Mail
rkaram@ucsd.edu
1st Degree
Medicine
University (1st Degree)
UFSCPA
About the PhD
Field of Research
Oncogenetics
Thesis Title
The role of nonsense-mediated mRNA decay (NMD) in the regulation of CDH1 gene expression and cancer development
Abstract
E-cadherin is an adhesion molecule that acts as a tumor suppressor protein by inhibiting tumor cell invasion and metastasis as a result of its ability to mediate cell-to-cell adhesion. Germline mutations of the E-cadherin...
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Supervisor(s)
Carla Oliveira, PhD (IPATIMUP, Portugal)
Co-Supervisor(s)
Miles F. Wilkinson, PhD (MD Anderson Cancer Center, USA)
University
Universidade do Porto
Laboratory
IPATIMUP & MD Anderson Cancer Center
City
Porto & Houston
Country
Portugal & USA
Date of Thesis Defence
2008-12-02
After the PhD (Current Situation)
Position
Postdoc
Institution
UCSD
View Institution website
City
San Diego
Country
USA

Relevant Publications
Bruno, I.*, Karam, R.*, Huang, L., Bhardwaj, A., Lou, C., Shum, E.Y., Gifford W.D., Pfaff, S.L., Wilkinson, M.F. Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell. 2011 May 20;42(4):500-10.
*co-first authors
View Publication
Karam, R., Carvalho, J., Bruno, I., Graziadio, C., Senz, J., Huntsman, D., Carneiro, F., Seruca, R., Wilkinson, M.F., Oliveira, C. (2008) The NMD mRNA surveillance pathway downregulates aberrant E-cadherin transcripts in gastric cancer cells and in CDH1 mutation carriers. Oncogene (27) , 4255-4260.
View Publication

Publications
Damin, A.P.S., Karam, R., Zettler C.G., Alexandre, C.O.P. Evidence for an association of Human Papillomavirus and Breast Carcinomas. Breast Cancer Research and Treatment, 2004;84: 131-137.
View Publication
Frebourg T, Oliveira C, Hochain P, Karam R, Manouvrier S, Graziadio C, Vekemans M, Hartmann A, Baert-Desurmont S, Alexandre C, Lejeune Dumoulin S, Marroni C, Martin C, Castedo S, Lovett M, Winston J, Machado JC, Attie T, Jabs EW, Cai J, Pellerin P, Triboulet JP, Scotte M, Le Pessot F, Hedouin A, Carneiro F, Blayau M, Seruca R. Cleft lip/palate and CDH1/E-cadherin mutations in families with hereditary diffuse gastric cancer. J Med Genet. 2006;43: 138-142
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Oliveira, C., Sousa, S., Pinheiro, H., Karam, R., Carriço, R., Senz, J., Kaurah, P., Carvalho, J., Pereira, R., Gusmão, L., Xiaogang, W., Yokota, J., Carneiro, F., Huntsman, D., Seruca, R. Quantification of epigenetic and genetic second hits in CDH1 during hereditary diffuse gastric cancer syndrome progression. Gastroenterology 2009; 136: 2137-2148.
View Publication
RNA Homeostasis Governed by Cell Type-Specific and Branched Feedback Loops Acting on NMD. Huang L, Lou CH, Chan W, Shum EY, Shao A, Stone E, Karam R, Song HW, Wilkinson MF. Mol Cell. 2011 Sep 16;43(6):950-61
View Publication

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INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology