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Class of 2004
Pinho, Sandra
1st Degree
About the PhD
Field of Research
Epigenetics and Stem Cell Biology
Thesis Title
Regulation of pluripotent states in human embryonic stem cells
A growing array of mouse and human pluripotent stem cell lines has been derived from the early embryo as well as from adult cells reprogrammed by ectopic expression of transcription factors – i.e. induced pluripotent stem...
Veronique Azuara
Imperial College London
Institute of Reproductive & Developmental Biology - Epigenetics and Development lab
Date of Thesis Defence
After the PhD (Current Situation)
Postdoctoral fellow
Characterization of the Mesenchymal Stem Niche Nestin+ Cells in Pathological Models of Bone Marrow Attrition and Expansion
Albert Einstein College of Medicine
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New York

Relevant Publications
Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P, Pombo A, O’Neill L, Azuara V. Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. Development 2010 Aug 137(15):2483-92.
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Frenette PS, Pinho S, Lucas D, Scheiermann C. Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine. Annual Review of Immunology. 2013 Jan 3.
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Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nature Medicine 2013 Apr;19(4):429-36.
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Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y, Frenette PS. PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med. 2013 Jul 1;210(7):1351-67.
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Poulos MG, Guo P, Kofler NM, Pinho S, Gutkin MC, Tikhonova A, Aifantis I, Frenette PS, Kitajewski J, Rafii S, Butler JM. Endothelial jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Reports. 2013 Sep 12;4(5):1022-34.
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Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, Mar JC, Bergman A & Frenette PS. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature Oct 2013. In Press
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Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM, Frenette PS. Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development. Dev Cell. 2014 May 12;29(3):340-9. doi: 10.1016/j.devcel.2014.03.013.
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Nat Med. 2014 Nov;20(11):1315-20. doi: 10.1038/nm.3707. Epub 2014 Oct 19.
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Bruns I*, Lucas D*, Pinho S*, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS. * These authors contributed equally.
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Science. 2015 Dec 3. pii: aad0084. [Epub ahead of print]
Fetal liver hematopoietic stem cell niches associate with portal vessels.
Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal-Estapé A, Pinho S, Ciero P, Nakahara F, Ma'ayan A, Bergman A, Merad M, Frenette PS.
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Banito A., Rashid S.T., Acosta J.C., Li S., Pereira C.F., Geti I., Pinho S., Silva J.C., Azuara V., Walsh M., Vallier L., Gil J. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 2009 Sep 15;23(18):2134-9. Epub 2009 Aug 20
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Albergaria A, Ribeiro AS, Pinho S, Milanezi F, Carneiro V, Sousa B, Sousa S, Oliveira C, Machado JC, Seruca R, Paredes J, Schmitt F. ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: a role for C/EBP{beta} in CDH3 gene activation. Hum Mol Genet. 2010 Apr 21
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Lucas D., Pinho S., and Frenette P. MSC Niche for Hematopoiesis. In Mesenchymal Stromal Cells. P. Hematti, and A. Keating, editors. Springer New York, 2013, pp 91-106.
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Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA. Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells. Cancer Lett. 2007 May 8;249(2):157-70. Epub 2006 Sep 11.
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Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA. Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.
Cancer Res. 2004 Oct 1;64(19):7050-7.
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Last Update
2013-03-18 16:08:23

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