Home
About the Program
Structure
Calendar 2017
Calendar 2016
Calendar 2015
Calendar 2014
Calendar 2013
Calendar 2012
Calendar 2011
Admissions
The Students
Class of 2016
Class of 2015
Class of 2014
Class of 2013
Class of 2012
Class of 2011
Class of 2010
Class of 2009
Class of 2008
Class of 2007
Class of 2006
Class of 2005
Class of 2004
Class of 2003
Class of 2002
Class of 2001
Class of 2000
Class of 1999
Class of 1997
Class of 1996
Research and Faculty
Coordinating Committee
Module Coordinators
Publications
PhD Degrees Completed
Events and Highlights
Contacts
Reserved Area
Forgot your password?
Class of 2004
Name
Pinho, Sandra
E-Mail
sandra.pinho@gmail.com
1st Degree
Biology
About the PhD
Field of Research
Epigenetics and Stem Cell Biology
Thesis Title
Regulation of pluripotent states in human embryonic stem cells
Abstract
A growing array of mouse and human pluripotent stem cell lines has been derived from the early embryo as well as from adult cells reprogrammed by ectopic expression of transcription factors – i.e. induced pluripotent stem...
more
Supervisor(s)
Veronique Azuara
University
Imperial College London
Laboratory
Institute of Reproductive & Developmental Biology - Epigenetics and Development lab
City
London
Country
UK
Date of Thesis Defence
2009-12-21
After the PhD (Current Situation)
Position
Postdoctoral fellow
Project
Characterization of the Mesenchymal Stem Niche Nestin+ Cells in Pathological Models of Bone Marrow Attrition and Expansion
Institution
Albert Einstein College of Medicine
View Institution website
City
New York
Country
USA

Relevant Publications
Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P, Pombo A, O’Neill L, Azuara V. Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. Development 2010 Aug 137(15):2483-92.
View Publication
Frenette PS, Pinho S, Lucas D, Scheiermann C. Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine. Annual Review of Immunology. 2013 Jan 3.
View Publication
Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nature Medicine 2013 Apr;19(4):429-36.
View Publication
Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y, Frenette PS. PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med. 2013 Jul 1;210(7):1351-67.
View Publication
Poulos MG, Guo P, Kofler NM, Pinho S, Gutkin MC, Tikhonova A, Aifantis I, Frenette PS, Kitajewski J, Rafii S, Butler JM. Endothelial jagged-1 is necessary for homeostatic and regenerative hematopoiesis. Cell Reports. 2013 Sep 12;4(5):1022-34.
View Publication
Kunisaki Y, Bruns I, Scheiermann C, Ahmed J, Pinho S, Zhang D, Mizoguchi T, Wei Q, Lucas D, Ito K, Mar JC, Bergman A & Frenette PS. Arteriolar niches maintain haematopoietic stem cell quiescence. Nature Oct 2013. In Press
View Publication
Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM, Frenette PS. Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development. Dev Cell. 2014 May 12;29(3):340-9. doi: 10.1016/j.devcel.2014.03.013.
View Publication
Nat Med. 2014 Nov;20(11):1315-20. doi: 10.1038/nm.3707. Epub 2014 Oct 19.
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Bruns I*, Lucas D*, Pinho S*, Ahmed J, Lambert MP, Kunisaki Y, Scheiermann C, Schiff L, Poncz M, Bergman A, Frenette PS. * These authors contributed equally.
View Publication
Science. 2015 Dec 3. pii: aad0084. [Epub ahead of print]
Fetal liver hematopoietic stem cell niches associate with portal vessels.
Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal-Estapé A, Pinho S, Ciero P, Nakahara F, Ma'ayan A, Bergman A, Merad M, Frenette PS.
View Publication
Banito A., Rashid S.T., Acosta J.C., Li S., Pereira C.F., Geti I., Pinho S., Silva J.C., Azuara V., Walsh M., Vallier L., Gil J. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev. 2009 Sep 15;23(18):2134-9. Epub 2009 Aug 20
View Publication

Publications
Albergaria A, Ribeiro AS, Pinho S, Milanezi F, Carneiro V, Sousa B, Sousa S, Oliveira C, Machado JC, Seruca R, Paredes J, Schmitt F. ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: a role for C/EBP{beta} in CDH3 gene activation. Hum Mol Genet. 2010 Apr 21
View Publication
Lucas D., Pinho S., and Frenette P. MSC Niche for Hematopoiesis. In Mesenchymal Stromal Cells. P. Hematti, and A. Keating, editors. Springer New York, 2013, pp 91-106.
View Publication
Pinho S, Marcos NT, Ferreira B, Carvalho AS, Oliveira MJ, Santos-Silva F, Harduin-Lepers A, Reis CA. Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells. Cancer Lett. 2007 May 8;249(2):157-70. Epub 2006 Sep 11.
View Publication
Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA. Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen.
Cancer Res. 2004 Oct 1;64(19):7050-7.
View Publication
Last Update
2013-03-18 16:08:23
INSTITUTIONS INVOLVED
Program financially supported by
the National Foundation for
Science and Technology