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| Name |
| Pinho, Andreia V. |
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| E-Mail |
| a.pinho@garvan.org.au |
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| 1st Degree |
| Biology (Microbiology and genetics) |
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| University (1st Degree) |
| FCUL |
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| About the PhD |
| Field of Research |
| Oncology |
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| Thesis Title |
| Pancreatic acinar cells plasticity. Senescence, EMT and p53. |
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| Abstract |
| Pancreatic acinar cells display plasticity to acquire distinct differentiation programs, being involved in diseases as chronic pancreatitis and pancreatic ductal adenocarcinoma. This work shows that acinar cells cultured... |
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| Pancreatic acinar cells display plasticity to acquire distinct differentiation programs, being involved in diseases as chronic pancreatitis and pancreatic ductal adenocarcinoma. This work shows that acinar cells cultured in suspension undergo dedifferentiation, acquiring a pancreatic embryonic progenitor phenotype. Dedifferentiated cells turn on a senescent program, associated with activation of p53 and Ras pathways. A similar progenitor-like phenotype with activation of senescence is present in experimental chronic pancreatitis. Acinar cultures lacking p53 overcome growth arrest and lose the pancreatic phenotype, undergoing an epithelial-mesenchymal transition, while maintaining the expression of pre-pancreatic endoderm and stem cell markers. In experimental acute pancreatitis, absence of p53 results in increased acinar cell proliferation and delayed regeneration. Our findings support a role for acinar cell dedifferentiation in the initiation of pancreatic diseases. A p53-dependent control of cell growth and epithelial differentiation constitutes a tumor suppressive mechanism that may limit PDAC development. |
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| Supervisor(s) |
| Francisco X. Real |
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| University |
| Pompeu Fabra, Barcelona |
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| Laboratory |
| IMIM (Barcelona) and CNIO (Madrid) |
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| Country |
| Spain |
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| Date of Thesis Defence |
| 2011-07-14 |
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| After the PhD (Current Situation) |
| Position |
| Postdoctoral Research Officer |
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| Institution |
| Pancreatic Carcinogenesis Group, Garvan Institute of Medical Research, The Kinghorn Cancer Centre |
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| City |
| Darlinghurst Sydney NSW |
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| Country |
| Australia |
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| Relevant Publications |
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| Pinho AV, Rooman I, Real FX. p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells.Cell Cycle. 2011 Apr 15;10(8):1312-21. |
| View Publication |
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| Pinho AV, Rooman I, Reichert M, De Medts N, Bouwens L, Rustgi AK, Real FX. Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis. Gut. 2011 Jul;60(7):958-66. |
| View Publication |
| Last Update |
| 2013-07-26 05:10:27 |
| The responsibility for this page contents is entirely of the student/alumnus. |
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Program financially supported by
the National Foundation for
Science and Technology
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